Evolution of microbial diversity during prolonged starvation
Evolution of microbial diversity during prolonged starvation
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DOI：
10.1073/pnas.96.7.4023
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发表时间：
1999-03-30
影响因子：
11.1
通讯作者：
Kolter, R
中科院分区：
文献类型：
--
作者：
Finkel, SE;Kolter, R
进化过程的模型假设新的等位基因通过随机自发突变出现在种群中。在特定环境中具有竞争优势的等位基因会被选择，表达这些有利突变的个体可以接管种群。我们利用大肠杆菌培养物在固定阶段长时间孵育，研究了其进化过程。即使经过数月的孵化，存活细胞的数量也显示出高度的动态。即使在初始条件相同的情况下，进化也沿着不同的路径进行。随着培养物的老化，更适突变体的接管不完全，导致多种突变形式共存，微生物多样性增加，因此，对静止期细菌群体的研究为理解自然群体多样性的进化提供了一个模型系统。
Models of evolutionary processes postulate that new alleles appear in populations through random spontaneous mutation. Alleles that confer a competitive advantage in particular environments are selected and populations can be taken over by individuals expressing these advantageous mutations. We have studied the evolutionary process by using Escherichia coli cultures incubated for prolonged periods of time in stationary phase. The populations of surviving cells were shown to be highly dynamic, even after many months of incubation. Evolution proceeded along different paths even when the initial conditions were identical. As cultures aged, the takeovers by fitter mutants were incomplete, resulting in the coexistence of multiple mutant forms and increased microbial diversity, Thus, the study of bacterial populations in stationary phase provides a model system for understanding the evolution of diversity in natural populations.