Too many transcription factors: positive and negative interactions.
Too many transcription factors: positive and negative interactions.
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发表时间：
1990-02
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通讯作者：
M. Karin
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作者：
M. Karin
真核转录因子可以根据其DNA结合结构域之间的保守序列分为几个家族。由于这种结构保守性，几种不同的反式作用因子通常可以与共同的结合位点相互作用。本文综述的最新研究结果表明，不同因子与共同靶位点的相互作用不一定导致等效的转录反应。虽然一些因子激活转录，但与同一位点结合的其他因子抑制这一过程。这里描述的例子说明了一个新兴的新模式的细胞调控介导的密切相关，但功能不同的转录因子，似乎竞争共同的结合位点。
Eukaryotic transcription factors can be classified into several families on the basis of conserved sequences among their DNA-binding domains. Because of such structural conservation, several different trans-acting factors can often interact with a common binding site. Recent findings reviewed herein indicate that the interaction of different factors with a common target site does not necessarily result in equivalent transcriptional responses. While some factors activate transcription, others that bind to the same site repress this process. The examples described here illustrate an emerging new mode of cellular regulation mediated by closely related but functionally distinct transcription factors that appear to compete for common binding sites.