The 24-hour dexamethasone suppression test in a clinical setting: relationship to diagnosis, symptoms, and response to treatment.
The 24-hour dexamethasone suppression test in a clinical setting: relationship to diagnosis, symptoms, and response to treatment.
复制标题
临床环境中的 24 小时地塞米松抑制试验：与诊断、症状和治疗反应的关系。
DOI：
--
复制
发表时间：
1979
影响因子：
17.7
通讯作者：
Demmie Mayfield
中科院分区：
文献类型：
--
作者：
Walter A. Brown;Robert Johnston;Demmie Mayfield
在临床环境中接受地塞米松抑制测试的54名男性精神病患者中，40%的重度抑郁症患者在地塞米松给药后24小时内摆脱了抑制，而所有精神分裂症、神经症、酗酒和药物滥用患者均表现出正常的垂体-肾上腺抑制。仅10%的抑郁症患者在地塞米松给药后8小时表现出抑制抵抗。在既往发作类型、家族史、症状或药物治疗方面，有或没有表现出逃避抑制的抑郁症患者之间没有差异。然而，那些表现出逃避的人往往对治疗反应更好，并被评为患有更严重的抑郁症。这些发现的理论和临床意义尚不清楚。
Of 54 male psychiatric patients undergoing dexamethasone suppression tests in a clinical setting, 40% of those with a major depressive disorder showed escape from suppression over the 24 hours after dexamethasone administration, while all of the patients with schizophrenia, neurosis, alcoholism,and drug abuse showed normal pituitary-adrenal suppression. Only 10% of the depressed patients showed resistance to suppression 8 hours after dexamethasone administration. There was no difference between depressed patients who did and did not show escape from suppression in type of previous episodes, family history, symptoms, or medication. However, those who showed escape tended to respond better to treatment and to be rated as having a more severe depression. The theoretical and clinical implications of these findings are not yet clear.