Prevalence and predictors of vitamin D-deficiency in frail older hospitalized patients.
Prevalence and predictors of vitamin D-deficiency in frail older hospitalized patients.
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DOI：
10.1186/s12877-018-0919-8
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发表时间：
2018-09-20
期刊：
影响因子：
4.1
通讯作者：
Pourhassan M
中科院分区：
文献类型：
--
作者：
Boettger SF;Angersbach B;Klimek CN;Wanderley ALM;Shaibekov A;Sieske L;Wang B;Zuchowski M;Wirth R;Pourhassan M
众所周知，维生素D缺乏症在老年人中非常普遍。然而，在体弱老年住院患者亚组中的患病率尚不清楚。我们试图调查虚弱老年住院患者维生素D缺乏的患病率和预测因素。回顾性分析了217例连续住院的老年患者入院时常规测量25-羟基维生素D [25（OH）D]，包括既往维生素D补充信息和老年评估。血清25（OH）D浓度< 20 ng/ml和在20和29.99 ng/ml之间分别被归类为缺乏和不足，而浓度≥30 ng/ml被认为是理想的。采用逐步二元逻辑回归模型评估年龄、性别和老年评估对低维生素D浓度患病率的同时影响。队列的平均年龄为81.6 ± 8.0岁（70.0%为女性）。平均血清25（OH）D为12.7 ± 12.9 ng/ml。在167例（77%）已知既往未补充维生素D的受试者中，仅21例（12.6%）血清浓度≥20 ng/ml，仅8例（4.2%）血清浓度≥30 ng/ml。在总人群中，146名（87.4%）参与者缺乏维生素D。尽管补充了维生素D，但50名参与者中有22名（44.0%）缺乏维生素D，只有19名（38.0%）的理想浓度≥30 ng/ml。在逐步逻辑回归分析中，只有先前摄入维生素D补充剂和高老年抑郁量表评分（GDS-15）与维生素D缺乏显著相关。在以前没有补充维生素D的虚弱老年住院患者中，维生素D浓度不足的患病率极高。因此，在开始补充之前常规测量维生素D状态的有用性在该患者组中似乎是值得怀疑的。
Vitamin D deficiency is known to be highly prevalent in older persons. However, the prevalence in the subgroup of frail older hospitalized patients is not clear. We sought to investigate the prevalence and predictors of vitamin D deficiency in frail older hospitalized patients. 217 consecutively geriatric hospitalized patients with routine measurements of 25-hydroxyvitamin D [25 (OH)D] at hospital admission were analyzed retrospectively, including information of previous vitamin D supplementation and the geriatric assessment. Serum 25 (OH)D concentrations < 20 ng/ml and between 20 and 29.99 ng/ml were classified as deficient and insufficient, respectively, whereas concentrations ≥30 ng/ml were considered as desirable. A stepwise binary logistic regression model was performed to assess the simultaneous effects of age, gender and geriatric assessments on the prevalence of low vitamin D concentration. Mean age of the cohort was 81.6 ± 8.0 years (70.0% females). Mean serum 25(OH)D was 12.7 ± 12.9 ng/ml. Of 167 (77%) subjects without known previous vitamin D supplementation, only 21 (12.6%) had serum concentrations ≥20 ng/ml and only 8 (4.2%) had desirable serum concentrations ≥30 ng/ml. In total population, 146 (87.4%) participants were vitamin D deficient. Despite vitamin D supplementation, 22 of 50 participants (44.0%) were vitamin D deficient and only 19 (38.0%) had desirable concentrations of ≥30 ng/ml. In a stepwise logistic regression analysis, only previous intake of vitamin D supplementation and high Geriatric Depression Scale score (GDS-15) were significantly associated with vitamin D deficiency. In the group of frail older hospitalized patients without previous vitamin D supplementation, the prevalence of inadequate vitamin D concentrations is extremely high. Therefore, usefulness of the routine measurement of vitamin D status before initiating of supplementation appears to be questionable in this patient group.
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影响因子：
5.8
作者：
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通讯作者：
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影响因子：
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影响因子：
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通讯作者：
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影响因子：
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