PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE - ROLE OF H-2D, H-2K, AND NON-H-2 ANTIGENS IN REJECTION
PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE - ROLE OF H-2D, H-2K, AND NON-H-2 ANTIGENS IN REJECTION
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DOI：
10.1097/00007890-197310000-00010
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发表时间：
1973-01-01
期刊：
影响因子：
6.2
通讯作者：
RUSSELL, PS
中科院分区：
文献类型：
--
作者：
CORRY, RJ;WINN, HJ;RUSSELL, PS
小鼠心脏作为主要血管化移植物异位移植。选择供体和受体提供与抗原组织不相容的组合，其特异性仅由H-2D区域的基因决定（B10）。BR→b6af1)，仅在H-2K区域（B10）。D2→b6af1)，在H-2以外的位点（129→B/10）；H-2D、H-2K和非h -2位点（A→（129 XB/10） f1）。在所有这些组合中，都有急性排斥发作，表现为明显冲动的急剧下降。心脏冲动的恢复通常在最初的下降后观察到，但除了B10的情况外，这种恢复是短暂的。BR在b6af1宿主中的移植物。在这种组合中，所有移植的心脏都至少部分恢复并长期存活。对于同种异体移植反应，心脏似乎比肾脏更脆弱，但比皮肤更脆弱。在研究的组合中，同种异体心脏和皮肤移植的存活时间密切相关。两种类型的移植物在仅涉及非h -2差异的情况下都发生了相对较早的急性排斥反应，并且当使用与移植物抗原特异性反应的抗血清处理小鼠时，它们的存活时间延长程度相似。不同种类同种异体移植物的生存差异归因于所激发的免疫反应强度的差异和对免疫物质攻击的敏感性的差异。
Mouse hearts were transplanted heterotopically as primarily vascularized grafts. Donors and recipients were selected to provide combinations in which there was histoincompatibility with respect to antigens whose specificities are determined by genes at the H-2D region only (B10. BR→ B6AF 1), at the H-2K region only (B10. D2→ B6AF 1), at loci other than H-2 (129→ B/10); and at H-2D, H-2K, and non-H-2 loci (A→(129 XB/10) F 1). In all of these combinations there were acute episodes of rejection as indicated by sharp declines in palpable impulse. Return of cardiac impulse was commonly observed after this initial decline but was short lived except in the case of B10. BR grafts in B6AF 1 hosts. In that combination all of the grafted hearts showed at least partial recovery and long-term survival. Hearts appear to be more vulnerable than kidneys but less vulnerable than skin to allograft reactions. In the combinationss studied there was a close relationship between the survival times of allografts of hearts and skin. Both types of grafts underwent relatively early and acute rejection in situations involving only non-H-2 differences and they had similar degrees of prolongation in survival time when placed on mice treated with antiserum specifically reactive with graft antigens. Differential survival of allografts of various kinds is ascribed to both differences in the intensity of the immune responses that are provoked and differences in sensitivity to attack by immune substances.