Safety of Lactobacillus Reuteri DSM 17938 in Healthy Children 2-5 Years of Age.
Safety of Lactobacillus Reuteri DSM 17938 in Healthy Children 2-5 Years of Age.
复制标题
罗伊氏乳杆菌 DSM 17938 对 2-5 岁健康儿童的安全性。
DOI：
10.1097/inf.0000000000002267
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Oberhelman,RichardA
中科院分区：
文献类型：
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作者：
Kosek,MargaretN;Peñataro-Yori,Pablo;Paredes-Olortegui,Maribel;Lefante,John;Ramal-Asayag,Cesar;Zamora-Babilonia,Marcelo;Meza-Sanchez,Graciela;Oberhelman,RichardA
Probiotics are increasingly used for diarrhea, but studies under the Food and Drug Administration and Investigational New Drug program are few. We conducted a phase-one placebo-controlled study of Lactobacillus reuteri DSM 17938 under Investigational New Drug program in 60 children 2–5 years of age (41 L. reuteri, 19 placebos) in a resource-constrained community in Peru. No differences in objective data on adverse events were noted, although some differences based on subjective parental reports for fever and diarrhea were seen.
