Plasma production rates of testosterone in normal adult men and women and in patients with the syndrome of feminizing testes.
Plasma production rates of testosterone in normal adult men and women and in patients with the syndrome of feminizing testes.
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正常成年男性和女性以及女性化睾丸综合征患者的血浆睾酮生成率。
DOI：
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发表时间：
1965
影响因子：
5.8
通讯作者：
K. Isurugi
中科院分区：
文献类型：
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作者：
A. Southren;S. Tochimoto;N. Carmody;K. Isurugi
通过单次注射氚化激素后测定血浆中睾酮的代谢清除率和睾酮的平均血浆非同位素浓度，对正常男性和女性以及2例完全型睾丸女性化综合征患者的每日血浆睾酮生成率进行了测量。后者的数值来自于上午9点、下午5点和晚上10点的血浆睾酮水平的平均值。在正常男性中发现了显著的昼夜变化，而在正常女性中则没有。受试者血浆睾酮平均浓度分别为0.52和0.06 μg/100 ml。正常男性的代谢清除率（1670-2084 I/天）大约是正常女性受试者（708-759 I/天）的两倍。这种差异似乎主要是由于雄性的内池体积（V,） （K2 = 0时的Vs）较大。血浆睾酮生成率分别为10.8、6.8、10.0和6.7 mg/d。
The daily plasma productionrate of testosterone was measured in normal men and women and in 2 patients with the complete form of the syndrome of feminizing testes from the product of the metabolic clearance rate of testosterone in plasma as determined following a single injection of the tritiated hormone, and the mean plasma nonisotopic concentration of the steroid. The latter values were obtained from the mean of plasma testosterone levels obtained at 9 am, 5 pm and 10 pm. A significant diurnal variation was found in the normal men but not in the normal women. The mean plasma concentration of testosterone in these subjects was 0.52 and 0.06 μg/100 ml, respectively. The metabolic clearance rates in the normal men (1670–2084 I/day) were approximately twice those obtained in normal female subjects (708–759 I/day). The difference appeared to be due primarily to a larger inner pool volume (V,) (Vs where K2 = 0) in the males. The plasma production rates of testosterone were 10.8, 6.8, 10.0 and 6.7 mg/day in ma...