ANTITUMOR COMPONENTS ISOLATED FROM THE CHINESE HERBAL MEDICINE COIX LACHRYMA-JOBI
ANTITUMOR COMPONENTS ISOLATED FROM THE CHINESE HERBAL MEDICINE COIX LACHRYMA-JOBI
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DOI：
10.1055/s-2006-959500
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发表时间：
1994-08-01
期刊：
影响因子：
2.7
通讯作者：
YAMADA, H
中科院分区：
文献类型：
--
作者：
NUMATA, M;YAMAMOTO, A;YAMADA, H
禾本科植物 Coh lachryma-jobi L. var. 的种子。 ma-yuen Stapf 是一种具有抗肿瘤活性的中药。通过碱水溶液法和硅胶柱色谱法对种子的丙酮提取物进行分级，以鉴定抗肿瘤成分。通过对可移植小鼠肿瘤的体内生长抑制试验测定的抗肿瘤活性归因于酸性部分。红外光谱和气液色谱显示该酸性部分由四种游离脂肪酸组成：棕榈酸、硬脂酸、油酸和亚油酸。
The seeds of the gramineous plant Coh lachryma-jobi L. var. ma-yuen Stapf are a traditional Chinese medicine possessing antitumor activity. An acetone extract of the seeds was fractionated by the aqueous alkali method and by silica gel column chromatography in order to identify the antitumor components. Antitumor activity, as assayed by an in vivo growth inhibition test on a transplantable mouse tumor, was attributed to an acidic fraction. Infrared spectroscopy and gas-liquid chromatography showed that this acidic fraction was composed of four free fatty acids: palmitic, stearic, oleic, and linoleic acids.