Association of metabolic syndrome with Alzheimer disease : A population-based study
Association of metabolic syndrome with Alzheimer disease : A population-based study
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DOI：
10.1212/01.wnl.0000234037.91185.99
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发表时间：
2006-09-12
期刊：
影响因子：
9.9
通讯作者：
Kuusisto, J.
中科院分区：
文献类型：
--
作者：
Vanhanen, M.;Koivisto, K.;Kuusisto, J.
目的：探讨代谢综合征(METS)与阿尔茨海默病(AD)的关系。方法：作者对980名随机选择的老年受试者进行了一项基于人群的研究。排除所有非阿尔茨海默病病例后，最终研究人群包括959名年龄在69岁至78岁之间的受试者(337名男性和622名女性)。甲硫氨酸的存在是根据国家胆固醇教育计划成人治疗小组III的标准来定义的，AD的诊断是基于国家神经和沟通障碍研究所以及中风-阿尔茨海默病和相关疾病协会的标准。结果：在研究对象中，418人(43.6%)患有代谢综合征。45例(4.7%)诊断为可能或可能的AD。患有甲硫氨酸的受试者比未患甲状旁腺素的受试者更容易发现AD(7.2vs2.8%；p<；0.001)。患有甲状旁腺素综合征的女性的AD患病率高于未患该综合征的女性(8.3vs1.9%；p<；0.001)，但在患有METS的男性患者中，AD的患病率并未增加(3.8vs3.9%；p=0.994)。单因素Logistic回归分析显示，蛋氨酸与AD显著相关(优势比[OR]2.71；95%可信区间1.44~5.10)。在包括载脂蛋白E4表型、教育程度、年龄和总胆固醇在内的多因素Logistic回归分析中，蛋氨酸与AD显著相关(OR 2.46；95%CI 1.27~4.78)。如果只将非糖尿病受试者纳入多变量分析，蛋氨酸仍与AD显著相关(OR 3.26；95%CI 1.45至7.27)。结论：代谢综合征与老年阿尔茨海默病相关。
Objective: To assess the association of metabolic syndrome (MetS) with Alzheimer disease (AD). Methods: The authors derived subjects from a population-based study of 980 randomly selected elderly subjects. After exclusion of all non-Alzheimer dementia cases, the final study population included 959 subjects (337 men and 622 women) aged 69 to 78 years. The presence of MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III) criteria, and the diagnosis of AD was based on the criteria of the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association. Results: Of the study subjects, 418 (43.6%) had MetS. Probable or possible AD was diagnosed in 45 subjects (4.7%). AD was more frequently detected in subjects with MetS than in subjects without MetS (7.2 vs 2.8%; p < 0.001). The prevalence of AD was higher in women with MetS vs women without the syndrome (8.3 vs 1.9%; p < 0.001), but in men with MetS, the prevalence of AD was not increased (3.8 vs 3.9%; p = 0.994). In univariate logistic regression analysis, MetS was significantly associated with AD (odds ratio [OR] 2.71; 95% CI 1.44 to 5.10). In multivariate logistic regression analysis including also apolipoprotein E4 phenotype, education, age, and total cholesterol, MetS was significantly associated with AD (OR 2.46; 95% CI 1.27 to 4.78). If only nondiabetic subjects were included in the multivariate analysis, MetS was still significantly associated with AD (OR 3.26; 95% CI 1.45 to 7.27). Conclusion: Metabolic syndrome is associated with Alzheimer disease in elderly subjects.