Crosstalk Between Agrin and Wnt Signaling Pathways in Development of Vertebrate Neuromuscular Junction
Crosstalk Between Agrin and Wnt Signaling Pathways in Development of Vertebrate Neuromuscular Junction
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DOI：
10.1002/dneu.22190
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发表时间：
2014-08-01
影响因子：
3
通讯作者：
Mei, Lin
中科院分区：
文献类型：
--
作者：
Barik, Arnab;Zhang, Bin;Mei, Lin
神经肌肉接头（NMJ）是运动神经元引起肌肉收缩的胆碱能突触。聚集蛋白及其共受体LRP 4和MuSK对脊椎动物NMJ的形成至关重要。本文综述了Wnt和Wnt信号分子在NMJ形成中的最新证据，包括肌肉β-连环蛋白可能的逆行机制。我们还提供了数据，Wnt 3a，7a，8a和10 b可以抑制agrin介导的AChR聚集。连同刺激作用的Wnt 9a，9 b，10 b，11和16 AChR集群在聚集蛋白的情况下，这些结果表明不同的作用Wnt配体在NMJ的发展。(C)2014 Wiley Periodicals，Inc.
Neuromuscular junction (NMJ) is a cholinergic synapse where motor neurons elicit muscle contraction. Agrin and its coreceptors LRP4 and MuSK are critical for vertebrate NMJ formation. This paper reviews recent evidence for Wnts and Wnt signaling molecules in NMJ formation including a possible retrograde mechanism by muscle beta-catenin. We also present data that Wnt3a, 7a, 8a and 10b could inhibit agrin-mediated AChR clustering. Together with the stimulating effect of Wnt9a, 9b, 10b, 11 and 16 on AChR clustering in the absence of agrin, these results suggest diverse roles for Wnt ligands in NMJ development. (C) 2014 Wiley Periodicals, Inc.