IMMUNOCYTOCHEMICAL ANALYSIS OF TUMOR-NECROSIS-FACTOR AND ITS RECEPTORS IN PARKINSONS-DISEASE
IMMUNOCYTOCHEMICAL ANALYSIS OF TUMOR-NECROSIS-FACTOR AND ITS RECEPTORS IN PARKINSONS-DISEASE
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DOI：
10.1016/0304-3940(94)90684-x
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发表时间：
1994-05-19
影响因子：
2.5
通讯作者：
HIRSCH, EC
中科院分区：
文献类型：
--
作者：
BOKA, G;ANGLADE, P;HIRSCH, EC
在帕金森病的黑质中观察到的活化的胶质细胞可能通过产生毒性物质如细胞因子参与神经细胞死亡的机制。在这些化合物中，肿瘤坏死因子-α。(TNF)之所以引起人们的兴趣是因为它能引起细胞死亡。我们在帕金森病患者的黑质中检测到TNF免疫反应性胶质细胞，但在对照组中没有。TNF受体的免疫反应性被发现在控制和帕金森病患者的多巴胺能神经元的细胞体和过程中，这表明黑质多巴胺能神经元可能是敏感的帕金森病产生的TNF。这些结果表明，TNF可能参与帕金森病发生的退行性过程，至少在原发性损伤诱导反应性神经胶质增生后。
Activated glial cells observed in the substantia nigra in Parkinson's disease may participate in the mechanism of nerve cell death by producing toxic substances such as cytokines. Among these compounds, tumor necrosis factor-alpha. (TNF) is of interest because it can provoke cell death. We detected TNF-immunoreactive glial cells in the substantia nigra of parkinsonian patients but not in those of control subjects. Immunoreactivity for TNF receptors was found in cell bodies and processes of most dopaminergic neurons of control and parkinsonian subjects, suggesting that nigral dopaminergic neurons might be sensitive to TNF produced in Parkinson's disease. These results suggest that TNF may participate in the degenerative processes occurring in Parkinson's disease, at least after a primary insult inducing a reactive gliosis.