Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development.
Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development.
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DOI：
10.1038/sj.bjc.6601327
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发表时间：
2003-11-17
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
基质金属蛋白酶（MMPs）最初被认为是在组织重塑过程中降解细胞外基质（ECM）的能力。它们在转移中的作用进一步突出了它们的重要性。临床试验已经评估了MMP抑制剂作为抗癌治疗剂的潜力，但没有成功。这些初步研究指出，MMPs在癌症中的复杂的多功能能力，如它们的功能所示，不仅作为晚期恶性肿瘤的尖锐介质，而且作为早期肿瘤发生的效应物。现在的研究表明，MMPs及其组织抑制剂通过细胞粘附的丧失、凋亡的逃避和细胞分裂的失调来影响肿瘤的发生和生长。金属蛋白酶轴的细胞外性质使其成为细胞命运的主要调节因子。
Matrix metalloproteinases (MMPs) were initially recognised for their extracellular matrix (ECM)-degrading capability during tissue remodelling. Their importance was further highlighted by their role in metastasis. Clinical trials have since evaluated the potential of MMP inhibitors as anticancer therapeutics, but without success. These initial studies point to the complex, multifunctional capacity of MMPs in cancer as shown by their function, not only as strident mediators of advanced malignancies, but also as effectors of early stage tumorigenesis. Research now shows that MMPs, and their tissue inhibitors, affect tumour initiation and growth through loss of cell adhesion, evasion of apoptosis, and deregulation of cell division. The extracellular nature of the metalloproteinase axis situates it as a master regulator of cell fate.
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影响因子：
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作者：
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