ARACHIDONIC-ACID STATUS CORRELATES WITH 1ST YEAR GROWTH IN PRETERM INFANTS
ARACHIDONIC-ACID STATUS CORRELATES WITH 1ST YEAR GROWTH IN PRETERM INFANTS
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DOI：
10.1073/pnas.90.3.1073
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发表时间：
1993-02-01
影响因子：
11.1
通讯作者：
TOLLEY, EA
中科院分区：
文献类型：
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作者：
CARLSON, SE;WERKMAN, SH;TOLLEY, EA
缺乏ω-6脂肪酸亚油酸的饮食会降低花生四烯酸（Ach）的浓度，并阻碍发育中的动物和人类的生长。然而，在喂养含亚油酸的商业配方奶粉的早产儿中，血浆磷脂酰胆碱Ach浓度从出生时的84 +/- 23 mg/L下降到4月龄时的最低点38 +/- 11 mg/L，标准化为足月儿的体重从2月龄开始逐渐下降。与商业配方相比，含有海洋油的配方进一步降低了血浆磷脂酰胆碱Ach（31 +/- 7 mg/L）和生长的最低值。乙酰胆碱状态（定义为平均血浆磷脂酰胆碱乙酰胆碱浓度在2，4，和6.5个月）与一个或多个措施的正常化增长，通过12个月。乙酰胆碱状态和母亲的身高解释了59%的体重差异和68%的身高差异。更好的Ach状态不是来自更高的能量摄入。早产儿有条件的乙酰胆碱缺乏症可能有助于一岁以上的生长。根据Ach状态与生长的关系，我们推测饮食中Ach可以改善早产儿一岁的生长。
Diets deficient in the omega-6 fatty acid linoleic acid reduce arachidonic acid (Ach) concentrations and retard growth of developing animals and humans. Nevertheless, plasma phosphatidylcholine Ach concentrations declined from 84 +/- 23 mg/liter at birth to a nadir of 38 +/- 11 mg/liter at 4 mo of age in preterm infants fed commercial formulas with linoleic acid, and weight normalized to that of term infants fell progressively beginning at 2 mo of age. The nadir of plasma phosphatidylcholine Ach (31 +/- 7 mg/liter) and growth were further reduced by formula containing marine oil compared with the commercial formulas. Ach status (defined as the mean plasma phosphatidylcholine Ach concentration at 2, 4, and 6.5 mo) correlated with one or more measures of normalized growth through 12 mo. Ach status and maternal height accounted for as much as 59% of the weight variance and 68% of the length variance in infants fed standard formulas. Better Ach status was not from higher energy intakes. A conditional Ach deficiency in preterm infants may contribute to growth over the first year of life. On the strength of the relationship between Ach status and growth, we hypothesize that dietary Ach could improve first year growth of preterm infants.