DNA‐Based Nanoarchitectures as Eminent Vehicles for Smart Drug Delivery Systems
DNA‐Based Nanoarchitectures as Eminent Vehicles for Smart Drug Delivery Systems
复制标题
DOI：
10.1002/adfm.202200924
复制
发表时间：
2022-03
影响因子：
19
通讯作者：
M. Komiyama;Narumi Shigi;K. Ariga
中科院分区：
文献类型：
--
作者：
M. Komiyama;Narumi Shigi;K. Ariga
为了在尖端医学中以最小的副作用有效地治愈疾病，必须有选择地将知名药物输送到患病部位，并允许仅在那里起作用。然而，以前提出的大多数药物递送系统(DDSS)还不够选择性和有效。本文综述了DNA纳米结构作为药物载体的DDS的最新研究进展。从短的DNA片段，各种复杂的纳米药物被制造出来，显示出前所未有的智能DDS功能。包裹的药物主要通过对DNA纳米结构的受控分解来释放。最近的注意力集中在使用适当的刺激来调节DDS中的每个过程(药物的输送、释放和其他)，以进一步改进治疗。作为调节的细胞内刺激，各种内源性化合物(例如，mRNA和酶)在靶细胞中特异性地丰富，被使用。或者，从组织外部提供物理扰动(例如，光照射)以控制DDS。通过在新概念方面结合多种战略，正在实现极其智能的分布式决策支持系统。DNA纳米体系结构中分子设计的完全自由保证了这些方法在未来的进一步发展。
In order to cure diseases efficiently with minimal side effects in sophisticated medicine, eminent drugs must be selectively delivered to diseased parts and allow to work only there. However, most of drug delivery systems (DDSs) previously proposed are not yet sufficiently selective and effective. This review covers recent developments of DDS in which DNA nanoarchitectures are employed as drug carriers. From short DNA fragments, a variety of complicated nanomedicines are fabricated to show unprecedentedly smart DDS functions. Encapsulated drugs are released mostly through controlled disassembly of DNA nanoarchitectures. Recent attention has been focusing to the use of appropriate stimuli to regulate each process in the DDS (delivery of drug, its release, and others) for further improved therapy. As intracellular stimuli for the regulation, various endogenous compounds (e.g., mRNA and enzymes), which are specifically abundant in target cells, are employed. Alternatively, physical perturbation (e.g., light irradiation) is provided from outside of tissues to control DDS. By combining multiple strategies in terms of new concepts, enormously smart DDSs are being achieved. Further progresses of these approaches in the future are guaranteed by complete freedom of molecular design in DNA nanoarchitectonics.