Plasminogen is required for efficient dissemination of B-burgdorferi in ticks and for enhancement of spirochetemia in mice
Plasminogen is required for efficient dissemination of B-burgdorferi in ticks and for enhancement of spirochetemia in mice
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DOI：
10.1016/s0092-8674(00)80298-6
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发表时间：
1997-06-27
期刊：
影响因子：
64.5
通讯作者：
Benach, JL
中科院分区：
文献类型：
--
作者：
Coleman, JL;Gebbia, JA;Benach, JL
宿主纤溶酶原激活系统在莱姆病的蜱传螺旋体伯氏疏螺旋体传播和侵袭中的作用，使用纤溶酶原（Plg）基因敲除小鼠进行了研究。在未进食蜱虫的螺旋体中未检测到PLG，但当蜱虫以宿主血液为食时会发生结合。纤溶酶原激活剂来源于宿主血粉。需要PLG来有效传播B。在蜱内的伯氏螺旋体和增强小鼠的螺旋体血症，但不是关键的传播和感染。这些结果为细菌利用脊椎动物蛋白酶在无脊椎动物载体中传播提供了证据，并强调了载体、病原体和宿主在促进生命周期和疾病方面的相互作用。
The role of the host plasminogen activation system in transmission of and invasion by Borrelia burgdorferi, the tick-borne spirochetal agent of Lyme disease, was investigated using plasminogen (Plg)-knockout mice. PLG was not detected in spirochetes from unfed ticks, but binding occurred as ticks fed on the host's blood. Plasminogen activators were derived from the host blood meal. PLG was required for efficient dissemination of B. burgdorferi within the tick and for enhancement of spirochetemia in mice but was not critical for transmission and infection. These results provide evidence for a bacterium using a vertebrate protease to disseminate in an invertebrate vector and underscores the interplay among vector, pathogen, and host in promoting the life cycle and disease.