Tetra- to dodecanuclear oxomolybdate complexes with functionalized bisphosphonate ligands: activity in killing tumor cells.
Tetra- to dodecanuclear oxomolybdate complexes with functionalized bisphosphonate ligands: activity in killing tumor cells.
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DOI：
10.1002/chem.201001626
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发表时间：
2010-12-10
影响因子：
4.3
通讯作者：
Dolbecq, Anne
中科院分区：
文献类型：
--
作者：
Compain, Jean-Daniel;Mialane, Pierre;Marrot, Jerome;Secheresse, Francis;Zhu, Wei;Oldfield, Eric;Dolbecq, Anne
我们报告的合成和表征的五种新型的含钼的聚氧乙烯（POM）-双膦酸盐配合物的核度范围从4至12，无论是完全还原，完全氧化或混合价（MoV，MoVI）钼，其中的双膦酸盐通过其两个膦酸酯基团以及去质子化的1-OH基团结合到POM簇。以[MoV 2 O 4（H2O）]2+或[MoVIO 4]2-与H2 O3 PC（C3 H6 NH 2）OPO 3 H2（阿仑膦酸）或其氨基苯酚衍生物在水中反应合成了化合物，并通过单晶X射线衍射和31 P NMR光谱进行了表征。（NH 4）6[（MoV 2 O 4）（MoVI 2 O 6）2（O3 PC（C3 H6 NH3）OPO 3）2]·12 H2O（1）是一种不溶性混合价态物种。[（C2 H5）2NH 2]4[MoV 4 O 8（O3 PC（C3 H6 NH3）OPO 3）2]·6 H2O（2）和[（C2 H5）2NH 2]6[MoV 4 O 8（O3 PC（C10 H14 NO）OPO 3）2]·18 H2O（4）具有相似的四核还原骨架。Li 8 [（MoV 2 O 4（H2O））4（O3 PC（C3 H6 NH3）OPO 3）4]·45 H2O（3）和Na 2 Rb 6 [（MoV 13 O 8）4（O3 PC（C3 H6 NH3）OPO 3）4]·26 H2O（5）分别是完全还原的八核和完全氧化的十二核POM的碱金属盐。体外研究了2-5（水溶性）对三种人肿瘤细胞系的活性。2-4具有弱但可测量的活性，但5具有约10 μM的IC 50值，基于全阿仑膦酸盐，约为母体阿仑膦酸盐分子活性的四倍，从而开辟了基于Mo-双膦酸盐簇的新型药物先导物开发的可能性。
We report the synthesis and characterization of five novel Mo-containing polyoxometalate (POM) – bisphosphonate complexes with nuclearities ranging from 4 to 12 and with either fully reduced, fully oxidized or mixed valence (MoV, MoVI) molybdenum in which the bisphosphonates bind to the POM cluster via their two phosphonate groups as well as a deprotonated 1-OH group. Compounds were synthesized in water from the reaction of [MoV2O4(H2O)]2+ or [MoVIO4]2− with H2O3PC(C3H6NH2)OPO3H2 (alendronic acid) or its aminophenol derivative, and were characterized by single crystal X-ray diffraction and 31P NMR spectroscopy. (NH4)6[(MoV2O4)(MoVI2O6)2(O3PC(C3H6NH3)OPO3)2]·12H2O (1) is an insoluble mixed valence species. [(C2H5)2NH2]4[MoV4O8(O3PC(C3H6NH3)OPO3)2]·6H2O (2) and [(C2H5)2NH2]6[MoV4O8(O3PC(C10H14NO)OPO3)2]·18H2O (4) contain a similar tetranuclear reduced framework. Li8[(MoV2O4(H2O))4(O3PC(C3H6NH3)OPO3)4]·45H2O (3) and Na2Rb6[(MoVI3O8)4(O3PC(C3H6NH3)OPO3)4]·26H2O (5) are alkali salts of, respectively, fully reduced octanuclear and fully oxidized dodecanuclear POMs. The activities of 2–5 (which are water soluble) against three human tumor cell lines were investigated in vitro. 2–4 had weak but measurable activity but 5 had IC50 values of ~10 μM, about four times the activity of the parent alendronate molecule, on a per- alendronate basis, opening up the possibility of the development of novel drug leads based on Mo- bisphosphonate clusters.
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影响因子：
2.8
作者：
Modec, B;Brencic, JV
通讯作者：
Brencic, JV
DOI：
10.1196/annals.1402.089
发表时间：
2007-01-01
期刊：
SKELETAL BIOLOGY AND MEDICINE, PT B
影响因子：
--
作者：
Russell, R. Graham G.;Xia, Zhidao;Ebetino, Frank H.
通讯作者：
Ebetino, Frank H.
影响因子：
5.3
作者：
Coscia M;Quaglino E;Iezzi M;Curcio C;Pantaleoni F;Riganti C;Holen I;Mönkkönen H;Boccadoro M;Forni G;Musiani P;Bosia A;Cavallo F;Massaia M
通讯作者：
Massaia M
DOI：
10.1107/s0108768190011041
发表时间：
1991-04-01
期刊：
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE
影响因子：
--
作者：
BRESE, NE;OKEEFFE, M
通讯作者：
OKEEFFE, M
影响因子：
4.6
作者：
Boglio, C;Lenoble, G;Tabet, JC
通讯作者：
Tabet, JC