Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children
Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children
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DOI：
10.2307/3434834
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发表时间：
2000-12-01
影响因子：
10.4
通讯作者：
Hooijkaas, H
中科院分区：
文献类型：
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作者：
Weisglas-Kuperus, N;Patandin, S;Hooijkaas, H
在健康的荷兰婴儿中，产前暴露于多氯联苯和二恶英与T细胞淋巴细胞数量的变化有关。我们调查了这些变化是否会持续到儿童后期，以及背景暴露于多氯联苯和二恶英是否与学龄前儿童传染病或过敏性疾病和体液免疫的流行有关。整个研究组由207对健康的母婴组成。我们通过母体和脐带血以及母乳喂养婴儿体内的多氯联苯118、138、153和180(西格玛多氯联苯)之和，通过母乳中的二恶英、平面和单邻位多氯联苯毒性当量(TEQ)水平来估计产前对多氯联苯和二恶英的暴露。目前的身体负荷是通过血浆中的西格玛多氯联苯估计的。通过家长问卷调查了解儿童传染病和变态反应性疾病的患病率，并通过初免后流行性腮腺炎、麻疹和风疹的抗体水平测定体液免疫水平。我们对85名儿童进行了淋巴细胞免疫标记物分析。出生前接触多氯联苯与出生前淋巴细胞、T细胞和CD3CD8(+)(细胞毒性)、CD4(+)CD45RO(+)(记忆)、T细胞受体(TCR)αβ(+)和CD3(+)人类白细胞抗原DR+(激活)T细胞的数量增加有关，学龄前儿童对腮腺炎和麻疹的抗体水平较低。经混杂因素调整后，产前接触多氯联苯与呼吸急促和喘息较少相关，而当前多氯联苯身体负担与反复中耳感染和水痘的发病率较高以及过敏反应的发病率较低相关。二恶英TEQ越高，咳嗽、胸闷和痰的患病率越高。我们的结论是，在荷兰学龄前儿童中，围产期背景暴露于多氯联苯和二恶英的影响持续到儿童时期，可能与更容易感染疾病有关。在生命早期获得的常见感染可能会防止过敏的发展，因此接触多氯联苯可能与过敏性疾病的发病率较低有关。
Prenatal exposure to polychlorinated biphenyls (PCBs) and dioxins is associated with changes in the T-cell lymphocyte population in healthy Dutch infants. We investigated whether these changes persist into later childhood and whether background exposure to PCBs and dioxins is associated with the prevalence of infectious or allergic diseases and humoral immunity at preschool age. The total study group consisted of 207 healthy mother-infant pairs. We estimated prenatal exposure to PCBs and dioxins by the sum of PCBs 118, 138, 153, and 180 (Sigma PCB) in maternal and cord plasma and in breast-fed infants by the dioxin, planar, and mono-ortho PCB toxic equivalent (TEQ) levels in human milk At 42 months of age, current body burden was estimated by the Sigma PCB in plasma. We assessed the prevalence of infectious and allergic diseases by parent questionnaire, and measured humoral immunity by antibody levels for mumps, measles, and rubella after primary vaccination. We performed immunologic marker analyses of lymphocytes in a subgroup of 85 children. Prenatal PCB exposure was associated with an increased number of lymphocytes, T-cells, and CD3CD8(+) (cytotoxic), CD4(+)CD45RO(+) (memory), T-cell receptor (TcR) alpha beta (+), and CD3(+)HLA-DR+ (activated) T cells and lower antibody levels to mumps and measles at preschool age. Adjusted for confounders, prenatal PCB exposure was associated with less shortness of breath with wheeze, and current PCB body burden was associated with a higher prevalence of recurrent middle-ear infections and of chicken pox and a lower prevalence of allergic reactions. A higher dioxin TEQ was associated with a higher prevalence of coughing, chest congestion, and phlegm. We conclude that in Dutch preschool children the effects of perinatal background exposure to PCBs and dioxins persist into childhood and might be associated with a greater susceptibility to infectious diseases. Common infections acquired early in life may prevent the development of allergy, so PCB exposure might be associated with a lower prevalence of allergic diseases.