Human telomere RNA: a potential target for ligand recognition.
Human telomere RNA: a potential target for ligand recognition.
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DOI：
10.2174/138161212799958378
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发表时间：
2012-05
影响因子：
3.1
通讯作者：
Yan Xu
中科院分区：
文献类型：
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作者：
Yan Xu
最近的一项发现表明，在哺乳动物细胞中，端粒DNA被转录成端粒重复序列RNA（简称TERRA）。TERRA RNA的存在可能揭示了染色体末端调控和保护的新水平，这可能促进对癌症和衰老等基本生物学过程的有价值的见解。揭示端粒RNA的结构和功能对了解端粒生物学和端粒相关疾病至关重要。事实上，其他人和我们已经通过核磁共振和x射线晶体学证明，人类端粒RNA形成g -四重结构。最近，我们通过使用光开关探针发现人类端粒RNA在活细胞中形成g -四重二聚体。近年来，关于端粒RNA g -四联体的研究取得了很大进展。本文综述了端粒RNA g -四重体的结构和拓扑结构以及端粒RNA g -四重体配体设计的最新进展；概述了该领域未来的挑战。
A recent finding demonstrated that telomere DNA is transcribed into telomeric repeat-containing RNA (referred to as TERRA) in mammalian cells. The existence of TERRA RNA may reveal a new level of regulation and protection of chromosome ends that could promote valuable insight into fundamental biological processes such as cancer and aging. Revealing the structure and function of telomere RNA will be essential for understanding telomere biology and telomere-related diseases. In fact, others and we have shown by NMR and x-ray crystallography that human telomere RNA forms G-quadruplex structures. More recently, we found that human telomere RNA forms a G-quadruplex dimer in the living cells by employing a light-switching probe. Recently, researches concerning the telomere RNA G-quadruplexes have made much progress. This review highlights the structures and topologies for telomere RNA G-quadruplex and recent efforts in the design of telomere RNA G-quadruplex ligands; outlines the future challenges in the field.