Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy.
Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy.
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大脑功能连通性的纵向变化：基于癫痫小鼠模型的病例报告研究。
DOI：
10.12688/f1000research.6570.2
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Cortes JM
中科院分区：
文献类型：
--
作者：
Erramuzpe A;Encinas JM;Sierra A;Maletic-Savatic M;Brewster AL;Anderson AE;Stramaglia S;Cortes JM
脑功能连接（FC）量化了大脑区域之间的统计依赖性。FC已被广泛用于解决与不同病理状态相比，控制条件下脑回路功能的改变，包括癫痫，一种主要的神经系统疾病。然而，FC也具有尚未开发的潜力，可以帮助我们了解大脑回路的病理转变。我们的假设是，FC可以区分全球大脑的互动在一个时间尺度的天。为此，我们提出了一个病例报告研究的基础上，小鼠癫痫模型和分析纵向颅内脑电图数据癫痫计算FC的变化，从最初的侮辱（癫痫持续状态）和潜伏期，当癫痫网络出现，在慢性癫痫，当无端癫痫发作发生自发事件。我们发现，在低频段的整体网络FC后立即癫痫持续状态被挑起，并单调增加后，在潜伏期。总的来说，我们的研究结果表明，FC的能力，以解决纵向变化的大脑连接在建立病理状态。
Brain Functional Connectivity (FC) quantifies statistical dependencies between areas of the brain. FC has been widely used to address altered function of brain circuits in control conditions compared to different pathological states, including epilepsy, a major neurological disorder. However, FC also has the as yet unexplored potential to help us understand the pathological transformation of the brain circuitry. Our hypothesis is that FC can differentiate global brain interactions across a time-scale of days. To this end, we present a case report study based on a mouse model for epilepsy and analyze longitudinal intracranial electroencephalography data of epilepsy to calculate FC changes from the initial insult (status epilepticus) and over the latent period, when epileptogenic networks emerge, and at chronic epilepsy, when unprovoked seizures occur as spontaneous events. We found that the overall network FC at low frequency bands decreased immediately after status epilepticus was provoked, and increased monotonously later on during the latent period. Overall, our results demonstrate the capacity of FC to address longitudinal variations of brain connectivity across the establishment of pathological states.