Relation of BMI and physical activity to sex hormones in postmenopausal women
Relation of BMI and physical activity to sex hormones in postmenopausal women
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DOI：
10.1038/oby.2006.191
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发表时间：
2006-09-01
期刊：
影响因子：
6.9
通讯作者：
Wang, C. Y.
中科院分区：
文献类型：
--
作者：
McTiernan, Anne;Wu, LieLing;Wang, C. Y.
目的：雌激素、雄激素和催乳素水平与绝经后乳腺癌的发病风险有关。然而，这些激素浓度的决定因素尚未确定。本研究的目的是检查内源性性激素的相关性。研究方法和程序：从妇女健康倡议饮食调整试验中随机选择267名绝经后妇女，评估肥胖、体力活动和饮食与雌二醇、游离雌二醇、雌酮、睾酮、游离睾酮、性激素结合球蛋白（SHBG）、雄烯二酮、脱氢表雄酮、硫酸脱氢表雄酮和泌乳素浓度之间的关系。结果：在对数转化激素的多元回归分析中，BMI与雌二醇（β = 0.031, p < 0.001）、雌二醇（β = 0.048, p < 0.001）、游离雌二醇（p = 0.062, p < 0.001）、游离睾酮（p = 0.017, p = 0.02）、催乳素（β = 0.012, p = 0.02）呈正相关，与SHBG （β = -0.02, p = 0.001）呈负相关。总体力活动（每周代谢当量任务）与雌酮、雌二醇和雄烯二酮浓度呈负相关（分别= -0.006、-0.007和-0.005），均为p
Objective: Levels of estrogen, androgen, and prolactin have been related to risk of postmenopausal breast cancer. However, the determinants of these hormone concentrations are not established. The purpose of this study was to examine correlates of endogenous sex hormones.Research Methods and Procedures: Associations among adiposity, physical activity, and diet and concentrations of estradiol, free estradiol, estrone, testosterone, free testosterone, sex hormone-binding globulin (SHBG), androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and prolactin were evaluated in 267 postmenopausal women randomly selected from the Women's Health Initiative Dietary Modification Trial.Results: In multiple regression analyses on log-transformed hormones, BMI was positively associated with estrone (beta = 0.031, p < 0.001), estradiol (beta = 0.048, p < 0.001), free estradiol (P = 0.062, p < 0.001), free testosterone (P = 0.017, p = 0.02), and prolactin (beta = 0.012, p = 0.02) and negatively associated with SHBG (beta = -0.02, p = 0.001). Total physical activity (metabolic equivalent tasks per week) was negatively associated with concentrations of estrone, estradiol, and androstenedione (beta = -0.006, -0.007, and -0.005, respectively, all p