Identification of a new, unorthodox member of the MAGE gene family
Identification of a new, unorthodox member of the MAGE gene family
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DOI：
10.1006/geno.1999.5870
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发表时间：
1999-07-15
期刊：
影响因子：
4.4
通讯作者：
Berenson, JR
中科院分区：
文献类型：
--
作者：
Pold, M;Zhou, J;Berenson, JR
存在几个肿瘤相关抗原家族，例如法师、GAGE/PAGE、PRAME、巴格和拉格/NY-ESO-1。这些抗原在肿瘤免疫学中特别感兴趣，因为它们的表达，除了睾丸和胎儿组织，似乎仅限于肿瘤细胞。我们已经确定了一个新的法师基因家族成员，MAGED 1。北方杂交和RT-PCR结果显示MAGED 1在正常成人组织中的表达水平与睾丸和胎肝中的表达水平相当。因此，MAGE 1不具有先前鉴定的法师家族基因的表达模式特征，表明MAGE家族基因的生物学比先前认为的更复杂。染色体定位将MAGED 1与染色体Xp11.23上的标记AFM 119 xd 6（DXS 1039）连锁。(C)北京：科学出版社.
Several tumor-associated antigen families, such as MAGE, GAGE/PAGE, PRAME, BAGE, and LAGE/NY-ESO-1, exist. These antigens are of particular interest in tumor immunology, because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells only. We have identified a novel member of the MAGE gene family, MAGED1. Northern hybridization and RT-PCR demonstrated that the expression level of MAGED1 in different normal adult tissues is comparable to that in testis and fetal liver. Thus, MAGED1 does not possess an expression pattern characteristic of previously identified MAGE family genes, suggesting that the biology of the MAGE-family genes is more complex than previously thought. Chromosome mapping linked MAGED1 tot marker AFM119xd6 (DXS1039) on chromosome Xp11.23. (C) 1999 Academic Press.