Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats
Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats
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DOI：
10.1248/bpb.b12-00525
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发表时间：
2012-10-01
影响因子：
2
通讯作者：
Itoh, Kouichi
中科院分区：
文献类型：
--
作者：
Hama, Sayuri;Ishihara, Yasuhiro;Itoh, Kouichi
脑出血的治疗通常是毫无意义的，尽管已经投入了相当大的努力来开发缺血性中风的治疗方法。本研究的目的是通过药物治疗来确定药物在改善脑出血后神经预后方面的影响。脑出血的自由基假说是基于血液成分及其降解产物引发的细胞毒性，如作为强有力的促氧化剂原子的血红素和铁。磺胺苯唑(SPZ)除抑制细胞色素P450产生超氧化物外，还具有清除活性氧等不同的作用机制。本研究探讨了SPZ在胶原酶诱导的脑出血大鼠脑损伤中的作用。结果表明，脑出血后全身应用SPZ可减轻大鼠纹状体功能障碍、脂质过氧化水平升高和脑水肿。这些结果表明，SPZ是一种潜在的有效治疗脑出血的方法，因为SPZ的作用始于脑出血后1h或3d。
Treatment of intracerebral hemorrhage is often pointless, although considerable effort has been devoted to developing treatments for ischemic stroke. The purpose of this study was to determine the influence of drugs in improving neurological outcomes with pharmaceutical therapy after intracerebral hemorrhage. The free-radical hypothesis for intracerebral hemorrhage is based on the cytotoxicity triggered by blood components and its degradation products, such as heme and iron as a potent pro-oxidant atom. Sulfaphenazole (SPZ) has a different mechanism such as reactive oxygen species scavenging, in addition to the inhibition of superoxide production by cytochrome P450. The present study investigated the properties of SPZ in collagenase-induced intracerebral hemorrhage rat brain damage. The results show that systemic SPZ treatment after intracerebral hemorrhage reduces striatal dysfunction, the elevation of lipid peroxidation, and brain edema in the rat. These results suggest that SPZ is a potentially effective therapeutic approach for intracerebral hemorrhage as the effect of SPZ was initiated for either 1 h or 3d post-intracerebral hemorrhage.