Membrane reorganization during chilling: implications for long-term stabilization of platelets.
Membrane reorganization during chilling: implications for long-term stabilization of platelets.
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DOI：
10.1006/cryo.2001.2355
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发表时间：
2001-09
期刊：
影响因子：
2.7
通讯作者：
F. Tablin;W. Wolkers;N. Walker;A. E. Oliver;N. Tsvetkova;K. Gousset;L. Crowe;J. Crowe
中科院分区：
文献类型：
--
作者：
F. Tablin;W. Wolkers;N. Walker;A. E. Oliver;N. Tsvetkova;K. Gousset;L. Crowe;J. Crowe
本文综述了血小板冷诱导活化的各种生物物理和生物化学事件。它描述了在冷藏和储存期间发生的由筏聚集体组成的大膜域的形成。它还提出了强有力的证据，血小板膜进行横向相分离，在长期储存在寒冷的，并建议筏聚集和横向相分离的关键事件，必须避免稳定血小板和存储它们在冷冻或干燥状态。
This essay is a review of the various biophysical and biochemical events that make up the factors responsible for platelet cold-induced activation. It describes the formation of large membrane domains composed of raft aggregates that occur during chilling and storage. It also presents strong evidence that platelet membranes undergo lateral phase separation during prolonged storage in the cold and suggests that raft aggregation and lateral phase separation are key events which must be obviated to stabilize platelets and store them either in the frozen or in the dry state.