Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo
Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo
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DOI：
10.1016/j.fitote.2009.08.018
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发表时间：
2010-04-01
期刊：
影响因子：
3.4
通讯作者：
Wei, Lili
中科院分区：
文献类型：
--
作者：
Li, Maoxing;Shang, Xiaofei;Wei, Lili
Lamtophlomis rotata (Benth ) Kudo is a perennial herb (Labiatae) used as the Tibetan traditional medicine with the effects of alleviating pain, detumescence, hemostasis, promoting blood circulation to remove blood stasis and reinforcing marrow In this study, we investigated the antinociceptive and anti-inflammatory activities of iridoid glycosides extract of L. rotata (IGLR) in mice Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times. Inhibit carrageenam-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by acetic acid in mice All of these results suggested that the iridoid glycosides extract possesses the significant antinociceptive and anti-inflammatory activities (C) 2009 Elsevier B V All rights reserved
