Spindle Cell Neoplasms of Lymph Nodes of Probable Reticulum Cell Lineage: True Reticulum Cell Sarcoma?
Spindle Cell Neoplasms of Lymph Nodes of Probable Reticulum Cell Lineage: True Reticulum Cell Sarcoma?
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可能的网状细胞谱系淋巴结梭形细胞肿瘤：真正的网状细胞肉瘤？
DOI：
10.1097/00000478-199005000-00001
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
R. Warnke
中科院分区：
文献类型：
--
作者：
L. Weiss;Gerald J. Berry;R. Dorfman;Peter Banks;E. Kaiserling;J. Curtis;J. Rosai;R. Warnke
原发于血淋巴器官的梭形细胞肿瘤极为罕见。我们报告四例发生在淋巴结内的罕见表型的梭形细胞肿瘤。4例中有2例具有交错网状细胞系的形态和免疫表型特征，表达多种巨噬细胞抗原和S-100蛋白，但不表达CD1。另外两例显示为树突状网状细胞谱系。两例患者均表达人类白细胞抗原DR、多种巨噬细胞抗原、补体受体C3b和C3d。1例表达R4/23，超微结构检查均可见桥粒。在所有四个病例中都检测到免疫球蛋白重链和β-T细胞受体基因的胚系构型。在第一组的两名患者中，一名肿瘤局部复发，另一名死于广泛转移。在第二组的两名患者中，分别在12个月和27个月的随访中都活得很好。
Primary spindle cell neoplasms involving hemalolymphoid organs are extremely rare. We present four cases of Spindle cell neoplasms of unusual phenotype arising within lymph nodes. Two of the four cases showed morphologic and immunophenotypic features suggestive of interdigitating reticulum cell lineage; these cases expressed several macrophage antigens and S-100 protein but not CDI. The other two cases showed evidence suggestive of dendritic reticulum cell lineage. Both cases expressed HLA-DR, several macrophage antigens, complement receptors C3b and C3d. one case expressed R4/23; both showed the presence of desmosomes on ultrastructoral examintion. A germline configuration for the immunoglobulin heavy chain and β-T-cell receptor genes was detected in all four cases. Of the two patients in the first group, one had local recurrence of tumor: the other died of widespread metastases. Of the two patients in the second group, both are alive and well at 12 and 27 months follow-up, respectively.