Acertannin prevented dextran sulfate sodium-induced colitis by inhibiting the colonic expression of IL-23 and TNF-alfa in C57BL.6J mice
Acertannin prevented dextran sulfate sodium-induced colitis by inhibiting the colonic expression of IL-23 and TNF-alfa in C57BL.6J mice
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醋单宁通过抑制 C57BL.6J 小鼠结肠中 IL-23 和 TNF-α 的表达来预防葡聚糖硫酸钠诱导的结肠炎
DOI：
10.1055/a-2037-2995
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发表时间：
2023
期刊：
影响因子：
2.7
通讯作者：
T. Okuda
中科院分区：
文献类型：
--
作者：
Y. Kimura;M. Taniguchi;T. Okuda
本研究探讨了Acertannan对葡聚糖硫酸钠（DSS）诱导的结肠炎的影响以及结肠细胞因子白细胞介素（IL）-1β水平的变化， IL-6、IL-10、IL-23、肿瘤坏死因子（TNF）-α、趋化因子单核细胞趋化蛋白（MCP）-1、血管内皮生长因子（VEGF）。红细胞、血小板和白细胞计数， 测定血细胞比容（Ht）、血红蛋白（Hb）和结肠细胞因子和趋化因子水平。口服给药的DSS处理小鼠的疾病活动指数（DAI）较低（30 和100 mg/kg）。Acertannitin（100 mg/kg）抑制DSS处理小鼠的红细胞计数和Hb和Ht水平的降低。Acertannin可防止DDS诱导的 结肠粘膜溃疡，并显着抑制结肠IL-23和TNF-α水平的升高。我们的研究结果表明，acertanninate有潜力作为一种治疗 炎症性肠病（IBD）。
The present study investigates the effects of acertannin on colitis induced by dextran sulfate sodium (DSS) and changes in the colonic levels of the cytokines interleukin (IL)-1β, IL-6, IL-10, IL-23, tumor necrosis factor (TNF)-α, the chemokine monocyte chemoattractant protein (MCP)-1, and vascular endothelial growth factor (VEGF).We examine the following: inflammatory colitis was induced in mice by 2% DSS drinking water givenad libitumfor 7 days. Red blood cell, platelets, and leukocyte counts and hematocrit (Ht), hemoglobin (Hb), and colonic cytokine and chemokine levels were measured. The disease activity index (DAI) was lower in DSS-treated mice orally administered acertannin (30 and 100 mg/kg) than in DSS-treated mice. Acertannin (100 mg/kg) inhibited reductions in the red blood cell count and Hb and Ht levels in DSS-treated mice. Acertannin prevented DDS-induced mucosal membrane ulceration of the colon and significantly inhibited the increased colonic levels of IL-23 and TNF-α. Our findings suggest that acertannin has potential as a treatment for inflammatory bowel disease (IBD).