Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies
Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies
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DOI：
10.1590/s0004-282x2009000600010
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发表时间：
2009-12-01
影响因子：
1.4
通讯作者：
Cavalheiro, Esper Abrão
中科院分区：
文献类型：
--
作者：
Arida, Ricardo Mario;Scorza, Fulvio Alexandre;Cavalheiro, Esper Abrão
癫痫患者一直被劝阻参加体育活动，因为担心它会加剧癫痫发作。临床和动物研究表明，减少癫痫发作的频率，以及降低敏感性，随后诱发癫痫发作后，运动计划。对接受体育训练的癫痫动物进行了实验研究分析。在所有研究中，体育训练能够减少癫痫大鼠自发性癫痫发作的次数。在大多数研究中，运动期间癫痫发作的发生率相对较低。在1680 h的运动过程中，癫痫动物无死亡。基于这些结果，鼓励癫痫患者进行非药物治疗和预防措施（如体育锻炼）似乎是合理的。
People with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Clinical and animal studies indicate a reduction of seizure frequency as well as decrease susceptibility to subsequently evoked seizures after an exercise program. Analyses from experimental studies of animals with epilepsy submitted to physical training programs were performed. in all studies the physical training was able to reduce the number of spontaneous seizures in rats with epilepsy. Seizure occurrence during exercise was relatively absent in the majority of studies. No death was found in animals with epilepsy during 1680 h of exercise. Based on these results it is plausible encouraging persons with epilepsy to non-pharmacological treatments and preventative measures such as physical exercise.