Joint effects of urinary arsenic methylation capacity with potential modifiers on arsenicosis: a cross-sectional study from an endemic arsenism area in Huhhot Basin, northern China.
Joint effects of urinary arsenic methylation capacity with potential modifiers on arsenicosis: a cross-sectional study from an endemic arsenism area in Huhhot Basin, northern China.
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DOI：
10.1016/j.envres.2014.04.036
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发表时间：
2014-07
影响因子：
8.3
通讯作者：
Qiang Zhang;Da Wang;Q. Zheng;Yi Zheng;Huihui Wang;Yuanyuan Xu;Xin Li;Guifan Sun
中科院分区：
文献类型：
--
作者：
Qiang Zhang;Da Wang;Q. Zheng;Yi Zheng;Huihui Wang;Yuanyuan Xu;Xin Li;Guifan Sun
低砷甲基化能力被认为与各种砷相关疾病有关。然而，砷甲基化能力和潜在修饰剂对砷中毒风险的协同作用尚不清楚。本研究评估了砷甲基化能力与几个危险因素对以皮肤病变为特征的砷中毒风险的联合作用。研究对象为呼和浩特盆地某地方性砷中毒病区的302名成人（砷中毒79名，非砷中毒223名）。测定尿中无机砷（iAs）、甲基胂酸（MMA）和二甲基胂酸（DMA）的含量，计算砷形态的百分比（iAs%、MMA%和DMA%）以及甲基化指数（一级甲基化指数PMI和二级甲基化指数SMI），以评估个体的砷甲基化能力。结果表明，甲基化能力较低，这是由较高的MMA%值和较低的DMA%和SMI值表示的，在调整多个混杂因素后，与砷中毒显著相关。较高MMA%值与年龄较大之间相互作用的相对超额风险为2.35（95% CI：-0.56，5.27），较高MMA%值与较低BMI之间相互作用的相对超额风险为1.08（95% CI：-1.20，3.36）。数据还表明，砷甲基化能力较低（DMA%和SMI较低）与年龄较大，BMI较低和男性性别具有协同效应。本研究的结果表明，较低的砷甲基化能力与砷中毒，某些危险因素可能会增加砷引起的皮肤病变的风险。
A lower arsenic methylation capacity is believed to be associated with various arsenic-related diseases. However, the synergistic effect of the arsenic methylation capacity and potential modifiers on arsenicosis risk is unclear. The current study evaluated the joint effect of the arsenic methylation capacity with several risk factors on the risk of arsenicosis characterized by skin lesions. In total, 302 adults (79 arsenicosis and 223 non-arsenicosis) residing in an endemic arsenism area in Huhhot Basin were included. Urinary levels of inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were determined, and the percentages of arsenic species (iAs%, MMA%, and DMA%), as well as two methylation indices (primary methylation index, PMI, and secondary methylation index, SMI), were calculated to assess the arsenic methylation capacity of individuals. The results showed that a lower methylation capacity, which is indicated by higher MMA% values and lower DMA% and SMI values, was significantly associated with arsenicosis after the adjustment for multiple confounders. The relative excess risk for interactions between higher MMA% values and older age was 2.35 (95% CI: −0.56, 5.27), and the relative excess risk for interactions between higher MMA% values and lower BMI was 1.08 (95% CI: −1.20, 3.36). The data also indicated a suggestive synergistic effect of a lower arsenic methylation capacity (lower DMA% and SMI) with older age, lower BMI, and male gender. The findings of the present study suggest that a lower arsenic methylation capacity was associated with arsenicosis and that certain risk factors may enhance the risk of arsenic-induced skin lesions.