LOCALIZATION OF NIGROSTRIATAL, NIGROTHALAMIC AND NIGROTECTAL NEURONS IN VENTRICULAR COORDINATES IN MACAQUES
LOCALIZATION OF NIGROSTRIATAL, NIGROTHALAMIC AND NIGROTECTAL NEURONS IN VENTRICULAR COORDINATES IN MACAQUES
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DOI：
10.1016/0306-4522(84)90259-8
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发表时间：
1984-01-01
期刊：
影响因子：
3.3
通讯作者：
YELNIK, J
中科院分区：
文献类型：
--
作者：
FRANCOIS, C;PERCHERON, G;YELNIK, J
黑质及其分支的地形首次分析猕猴通过使用地形技术的基础上心室标志。这项研究表明，稳定的轮廓黑质及其细分在各种猕猴。通过定义8个垂直横向水平，将4个细分的前后顺序标准化，定期间隔并系统地用于每个实验病例。用辣根过氧化物酶逆行追踪技术鉴定黑质神经元向纹状体、丘脑和上级丘的轴突。黑质纹状体标记神经元主要分布在同侧丘脑腹侧，但也有散在分布于混合部背侧和网状部腹侧的。在猴子中证明了交叉黑质纹状体通路的存在。黑质丘脑标记神经元在整个网状部的吻侧水平和仅在内侧部分的尾部水平。黑质顶盖标记神经元也见于整个网状部的吻侧水平，但在尾部，它们仅限于网状部的外侧部分和外侧部。这3个黑质成分可能在黑质的某些水平重叠。这与分支轴突的存在有关。有一个强烈的倾向，黑顶盖神经元分离的黑丘脑的，并位于侧在猴子。两个nigrotectal组件的基础上，他们的地形和他们的胞体大小：1大的胞体位于pars lateralis，可能是特定的灵长类动物，和其他较小的胞体位于pars reticulata。这2个组件可能表明存在2个不同的功能系统。
The topography of the substantia nigra and its subdivisions was first analyzed in macaques by using a topographic technique based on ventricular landmarks. This study shows the stability of the contours of the substantia nigra and its subdivisions in various species of macaques. The anteroposterior sequence of 4 subdivisions was standardized by defining 8 verticotransverse levels, regularly interspaced and systematically used for each experimental case. Neurons of the substantia nigra sending axons to the striatum, thalamus and superior colliculus were identified by the technique of retrograde transport of horseradish peroxidase. The nigrostriatal labeled neurons were essentially located in the ipsilateral pars compacta but also scattered dorsally in the pars mixta and ventrally in the pars reticulata. The existence of a crossed nigrostriatal pathway was demonstrated in monkeys. Nigrothalamic labeled neurons were found in the whole pars reticulata at rostral levels and only in the medial part at more caudal levels. Nigrotectal labeled neurons were also found in the whole pars reticulata at rostral levels, but caudally, they were confined to the lateral part of the pars reticulata and the pars lateralis. These 3 nigral components may overlap at some levels of the substantia nigra. This is discussed in relation to the existence of branched axons. There is a strong tendency of the nigrotectal neurons to be segregated from the nigrothalamic ones and to be laterally located in monkeys. Two nigrotectal components were identified on the basis of their topography and their somata size: 1 with large somata located in the pars lateralis, probably specific to primates, and the other with smaller somata located in the pars reticulata. These 2 components may indicate the existence of 2 different functional systems.