Interleukin-27 levels in patients with myasthenia gravis.
Interleukin-27 levels in patients with myasthenia gravis.
复制标题
重症肌无力患者的白细胞介素 27 水平。
DOI：
10.1515/tnsci-2020-0134
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发表时间：
2020
影响因子：
2.1
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Liu XJ;Zhang LJ;Yi M;Li LM;Wang J;Qi Y;Zhao P;Zhang DQ;Yang L
白细胞介素-27（IL-27）属于IL-12家族，通过调节叉头框P3（FoxP 3）的表达和功能影响T细胞的功能。本研究检测了59例重症肌无力（MG）患者和35例健康对照者（HC）血清IL-27水平。其中32例MG患者接受静脉注射免疫球蛋白（IVIG）（0.4 g/kg/d，连续5 d）。在治疗前后收集IL-27水平并进行比较研究。最后，我们评估了IL-27水平与MG临床特征的相关性。结果表明，MG患者血清IL-27水平显著高于HC患者。同时，IVIG治疗后检测到显著降低。IL-27水平与MG日常生活活动和定量MG评分呈正相关。IL-27可能参与了MG的发病过程，可作为MG的早期诊断和预后判断的指标。此外，IL-27可通过调节特异性免疫信号传导和维持免疫稳态而用作MG治疗的靶点。
Interleukin-27 (IL-27), which belongs to IL-12 family, influences the function of T cells (Tregs) through regulating the expression, and function of forkhead box P3 (FoxP3). In this study, we detected the IL-27 serum levels in 59 myasthenia gravis (MG) patients and 35 healthy controls (HCs). Among them, 32 MG patients received immunoglobulin intravenous (IVIG) injections (0.4 g/kg per day for 5 consecutive days). IL-27 levels were collected before and after the treatments and subjected to a comparative study. Finally, we assessed the correlations of IL-27 levels with the clinical characteristics of MG. As a result, serum IL-27 levels were significantly higher in MG patients than those in the HCs. Meanwhile, significant reduction was detected after the IVIG treatment. IL-27 levels positively correlated with both MG activities of daily living and quantitative MG score. IL-27 may participate in the pathogenesis of MG and can be used as an early marker for the diagnosis and prognosis of MG. In addition, IL-27 can be used as a target for MG treatment through the regulation of specific immune signaling and maintaining immune homeostasis.