Fear of movement-related pain disturbs cortical preparatory activity after becoming aware of motor intention
Fear of movement-related pain disturbs cortical preparatory activity after becoming aware of motor intention
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DOI：
10.1016/j.bbr.2021.113379
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发表时间：
2021-06-04
影响因子：
2.7
通讯作者：
Morioka, Shu
中科院分区：
文献类型：
--
作者：
Osumi, Michihiro;Sumitani, Masahiko;Morioka, Shu
已知对运动相关疼痛的恐惧会干扰慢性疼痛患者的运动准备过程。本研究旨在利用利贝特生物钟和脑电图（EEG）研究恐惧运动相关疼痛对运动准备性脑活动影响的神经机制。健康的参与者被要求在观看旋转的Libet时钟指针时按下按钮，并在他们做出“决定”用右手食指按下按钮时报告时钟上的数字（“W时间”）。在按下按钮后，立即向左手的背部传递疼痛的电刺激，使参与者感到害怕运动（按钮按压相关疼痛）。我们发现，运动相关疼痛的恐惧导致W时间提前，准备电位（RP）的幅度增加后，意识到运动意图出现。此外，在参与者意识到自己的运动意图后，对运动相关疼痛的恐惧会导致内侧额叶皮质、辅助运动区、扣带运动区和初级运动皮质过度激活。这种过度激活可能是由于逃避痛苦体验的未实现愿望与执行所需运动任务的动机之间的冲突。
Fear of movement-related pain is known to disturb the process of motor preparation in patients with chronic pain. In the present study, we aimed to clarify the neural mechanisms underlying the influence of fear movementrelated pain on motor preparatory brain activity using Libet's clock and electroencephalography (EEG). Healthy participants were asked to press a button while watching a rotating Libet's clock-hand, and report the number on the clock ("W time") when they made the "decision" to press the button with their right index finger. Immediately after pressing the button, a painful electrical stimulus was delivered to the dorsum of the left hand, causing participants to feel fear of movement (button press-related pain). We found that fear of movementrelated pain caused the W time to be early, and that the amplitudes of readiness potentials (RPs) increased after awareness of motor intention emerged. In addition, fear of movement-related pain caused over-activation of the medial frontal cortex, supplementary motor area, cingulate motor area, and primary motor cortex after participants became aware of their motor intention. Such over-activation might result from conflict between the unrealized desire to escape from a painful experience and motivation to perform a required motor task.