INVIVO AND INVITRO SODIUM-PUMP ACTIVITY IN SUBJECTS WITH THYROTOXIC PERIODIC PARALYSIS
INVIVO AND INVITRO SODIUM-PUMP ACTIVITY IN SUBJECTS WITH THYROTOXIC PERIODIC PARALYSIS
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DOI：
10.1136/bmj.303.6810.1096
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发表时间：
1991-11-02
影响因子：
--
通讯作者：
SWAMINATHAN, R
中科院分区：
文献类型：
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作者：
CHAN, A;SHINDE, R;SWAMINATHAN, R
Objective - To examine whether sodium pump activity plays a part in the pathogenesis of thyrotoxic periodic paralysis.Design - Measurement of platelet sodium-potassium ATPase and in vivo sodium pump activities in healthy subjects and thyrotoxic subjects with and without paralysis.Setting - University hospital in Hong Kong.Subjects - 21 healthy subjects, 23 untreated thyrotoxic subjects, 13 untreated men with periodic paralysis, seven treated thyrotoxic subjects, and six treated men with periodic paralysis.Main outcome measures - Platelet Na+, K+-ATPase activity and plasma rubidium concentration after oral loading.Results - Median (range) platelet Na+, K+-ATPase activity in thyrotoxic subjects was 253 (169-821) mu-mol inorganic phosphate/h/g protein-significantly higher than that in healthy subjects (134 (81-180) mu-mol/h/g protein; p < 0.001). Na+, K+-ATPase activity in those with periodic paralysis was 374 (195-11%) mu-mol/h/g protein, again significantly higher than that in healthy subjects (p < 0.001) and that in other thyrotoxic subjects (p < 0.01) despite similar degrees of hyperthyroidism. Activities in treated thyrotoxic subjects with and without periodic paralysis were 148 (110-234) and 131 (86-173) mu-mol/h/g protein respectively. Mean (95% confidence interval) plasma rubidium concentration five hours after oral administration in thyrotoxic subjects (7.0 (6.6 to 7.5) mu-mol/l) was significantly lower than in healthy subjects (10.2 (9.5 to 10.9) mu-mol/l; p < 0.001) and higher than in those with periodic paralysis (6.0 (5.7 to 6.3) mu-mol/l; p < 0.01).Conclusions - Sodium pump activity in untreated subjects with periodic paralysis is higher than in other thyrotoxic subjects, and this may be responsible for the hypokalaemia.
