Liquid phase deposited titania coating to enable in vitro apatite formation on Ti6Al4V alloy
Liquid phase deposited titania coating to enable in vitro apatite formation on Ti6Al4V alloy
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DOI：
10.1007/s10856-013-5078-z
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发表时间：
2014-02-01
影响因子：
3.7
通讯作者：
Osaka, Akiyoshi
中科院分区：
文献类型：
--
作者：
Hayakawa, Satoshi;Masuda, Yoshitake;Osaka, Akiyoshi
最近开发的“GRAPE（A（R））技术”为钛或钛合金植入物提供了体外自发磷灰石形成能力，这需要适当设计的间隙和在空气中的最佳热处理。在这项研究中，在GRAPE（A（R））装置中对齐成对的样本之前，在空气中热氧化钛合金和商业纯（cp）钛基材，即，钛合金和CP钛基底以最佳间隙宽度（空间设计）彼此平行排列。采用液相沉积技术在钛合金表面制备了二氧化钛涂层。然后，将它们浸泡在Kokubo的模拟体液（SBF，pH 7.4，36.5 A ℃）中7天，以确认在特定空间设计下在基底上的体外磷灰石形成。利用液相沉积技术制备的锐钛矿型二氧化钛涂层在7天内沉积了磷灰石颗粒，并显示出磷灰石的X射线衍射。另一方面，热氧化钛合金基板在空气中和未经处理的标本没有显示任何磷灰石的X射线衍射。这些结果表明，当LPD法制备的锐钛矿型TiO2涂层平行于热氧化纯钛基体时，在最佳间隙宽度下，诱导磷灰石在涂层上异质形核。
A recently developed "GRAPE(A (R)) technology" provides titanium or titanium alloy implants with spontaneous apatite-forming ability in vitro, which requires properly designed gaps and optimum heat treatment in air. In this study, titanium alloy and commercially pure (cp) titanium substrates were thermally oxidized in air before aligning pairs of specimens in the GRAPE(A (R)) set-up, i.e., titanium alloy and cp titanium substrates were aligned parallel to each other with optimum gap width (spatial design). A liquid phase deposition (LPD) technique was employed for titania coatings on titanium alloy substrate. Then, they were soaked in Kokubo's simulated body fluid (SBF, pH 7.4, 36.5 A degrees C) for 7 days to confirm the in vitro apatite formation on the substrates under the specific spatial design. Anatase-type titania coatings fabricated by using LPD technique led to the deposition of apatite particles within 7 days and showed apatite X-ray diffraction. On the other hand, thermally oxidized titanium alloy substrate in air and non-treated specimens did not show any apatite X-ray diffraction. These results indicated that the heterogeneous nucleation of apatite induced on anatase-type titania coating prepared by LPD technique when it was aligned parallel to thermally oxidized cp titanium substrate with optimum gap width.