Serotonin transporter availability in impulsive aggressive personality disordered patients: a PET study with [11C]DASB.
Serotonin transporter availability in impulsive aggressive personality disordered patients: a PET study with [11C]DASB.
复制标题
冲动攻击性人格障碍患者中血清素转运蛋白的可用性：一项使用 [11C]DASB 的 PET 研究。
DOI：
10.1016/j.jpsychires.2014.07.025
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发表时间：
2014
影响因子：
4.8
通讯作者：
Siever,LarryJ
中科院分区：
文献类型：
--
作者：
vandeGiessen,Elsmarieke;Rosell,DanielR;Thompson,JudyL;Xu,Xiaoyan;Girgis,RagyR;Ehrlich,Yosefa;Slifstein,Mark;Abi-Dargham,Anissa;Siever,LarryJ
Serotonin (5-HT) has consistently been implicated in the pathophysiology of impulsive aggression. In the current study, we tested the hypothesis that 5-HT transporter (5-HTT) binding is reduced in the anterior cingulate cortex (ACC) in impulsive aggressive patients. Additionally, we characterized pathological personality dimensions, with a specific focus on callousness (i.e. emotional indifference, a facet of psychopathy). Callousness is putativelypositivelycorrelated with presynaptic 5-HT, and thus could potentially confound the hypothesizednegativerelation between 5-HTT levels and trait aggression.We determined 5-HTT binding with positron emission tomography and [11C]DASB in 29 patients with intermittent explosive disorder (IED-IR) and 30 controls. We assessed group differences in 5-HTT binding in the pregenual ACC, amygdala and subcortical regions and examined correlations between 5-HTT binding and clinical measures.There were no significant differences in 5-HTT binding between IED-IR patients and controls. Trait callousness exhibited a significant, positive correlation with ACC 5-HTT availability. Among IED-IR patients, a trend-level negative partial correlation was observed between trait aggression and ACC 5-HTT availability, while covarying for callousness and age. Exploratory analyses revealed a significant negative correlation between state aggression levels and 5-HTT availability in subcortical regions, namely striatum and thalamus.We did not confirm our hypothesis of lower ACC 5-HTT availability in impulsive aggressive patients, however, the positive correlation between callousness and ACC 5-HTT availability likely played a confounding role. Subtypes of aggression (e.g., reactive vs. proactive aggression), which are differentially associated with pathological personality dimensions such as callousness, may contribute to variability between 5-HT functioning and aggression.
