High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules
High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules
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DOI：
10.1016/j.bios.2006.09.021
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发表时间：
2007-04-15
影响因子：
12.6
通讯作者：
Handa, Hiroshi
中科院分区：
文献类型：
--
作者：
Sandhu, Adarsh;Kumagai, Yoshimichi;Handa, Hiroshi
利用微霍尔生物传感器检测磁性标记的生物分子是一种很有前途的监测生物分子识别过程的方法。标准系统的测量效率受到磁珠到达霍尔器件的感测区域所花费的时间的限制。在这里，微电流线与霍尔效应结构集成，以通过在电流线中流动的局部电流产生的场梯度来操纵磁珠的位置。在电流通过电流线的几秒钟内，珠粒积聚在传感器表面上。利用电流线与霍尔生物传感器的集成实现了磁珠的实时检测。这些结果在建立霍尔生物传感器平台作为监测生物分子反应的医学应用的有效和廉价的手段是有希望的。(c)2006 Elsevier B.V.版权所有
Detection of magnetically labeled biomolecules using micro-Hall biosensors is a promising method for monitoring biomolecular recognition processes. The measurement efficiency of standard systems is limited by the time taken for magnetic beads to reach the sensing area of the Hall devices. Here, micro-current lines were integrated with Hall effect structures to manipulate the position of magnetic beads via field gradients generated by localized currents flowing in the current lines. Beads were accumulated onto the sensor surface within seconds of passing currents through the current lines. Real-time detection of magnetic beads using current lines integrated with Hall biosensors was achieved. These results are promising in establishing Hall biosensor platforms as efficient and inexpensive means of monitoring biomolecular reactions for medical applications. (c) 2006 Elsevier B.V. All rights