Contrasting pathogenesis of atopic dermatitis and psoriasis-Part I: Clinical and pathologic concepts
Contrasting pathogenesis of atopic dermatitis and psoriasis-Part I: Clinical and pathologic concepts
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DOI：
10.1016/j.jaci.2011.01.053
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发表时间：
2011-05-01
影响因子：
14.2
通讯作者：
Krueger, James G.
中科院分区：
文献类型：
--
作者：
Guttman-Yassky, Emma;Nograles, Kristine E.;Krueger, James G.
特应性皮炎和牛皮癣是两种最常见的炎症性皮肤病。它们的相似之处在于它们都是复杂的遗传性疾病，涉及编码免疫成分和调节表皮细胞分化的结构蛋白的基因。每种疾病的特征是表皮角质形成细胞增殖和表皮角质化或终末分化异常；皮肤损伤含有 T 细胞、树突状细胞和其他类型白细胞的免疫浸润。我们回顾了这些疾病之间的相似之处以及表皮屏障缺陷和免疫细胞的差异。我们还提出了基于免疫细胞亚群平衡差异的发病机制，这些差异可能导致区分这些疾病的表型。这篇由两部分组成的综述的第一部分重点关注疾病的临床和病理特征；第二部分讨论特应性皮炎和牛皮癣之间免疫细胞亚群的差异以及最近的治疗策略。 （过敏临床免疫杂志 2011 年；127：1110-8。）
Atopic dermatitis and psoriasis are 2 of the most common inflammatory skin diseases. They are similar in that they are complex inherited diseases involving genes that encode immune components and structural proteins that regulate differentiation of epidermal cells. Each disease is characterized by proliferation of epidermal keratinocytes and abnormal cornification or terminal differentiation in the epidermis; skin lesions contain immune infiltrates of T cells, dendritic cells, and other types of leukocytes. We review similarities between the diseases and differences in epidermal barrier defects and immune cells. We also propose mechanisms of pathogenesis based on differences in the balance of immune cell subsets that could cause the phenotypes that distinguish these diseases. The first part of this 2-part review focuses on the clinical and pathologic features of the diseases; the second part discusses differences in immune cell subsets between atopic dermatitis and psoriasis and recent therapeutic strategies. (J Allergy Clin Immunol 2011;127:1110-8.)