Causes of hypouricemia among outpatients
Causes of hypouricemia among outpatients
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DOI：
10.1309/h3ttuvdbe75d6n6p
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发表时间：
2008-09-01
期刊：
影响因子：
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通讯作者：
Sahin, Ozlem
中科院分区：
文献类型：
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作者：
Bugdayci, Guler;Balaban, Yasemin;Sahin, Ozlem
背景：本研究的目的不是检查我们门诊患者低尿酸血症的比例和根本原因。还研究了低尿酸血症和尿酸尿以及其他肾小管缺陷之间的关联。方法：采用尿酸酶法测定18,330份血清样本中的血清尿酸水平。低尿酸血症定义为血清尿酸水平低于2.0 mg/dL。尿酸排泄分数（FEUA）高于10%被认为是病理性尿酸尿。结果：我们的患者群体中低尿酸血症的发生率为0.51%（94/18,330）。此外，通过单变量分析，低尿酸血症与年龄、性别、饮食、药物以及茶和咖啡的摄入量有关。多变量分析显示，FEUA、药物和茶的摄入与低尿酸血症有关。结论：低尿酸血症在我们的患者中相对罕见，当发生时，通常是由不适当的尿酸尿引起的。
Background: The aim of this study was no examine the ratio and underlying causes of hypouricemia in patients visiting our outpatient clinics. The assoication between hypouricemia and uricosuria and other renal tubular defects was also studied.Methods: Serum uric acid levels were determined by uricase methods in 18,330 serum samples. Hypouricemia was defined as a serum uric acid level less than 2.0 mg/dL. Fractional excretion of uric acid (FEUA) higher than 10% was considered as pathological uricousuria.Results: The frequency of hypouricemia in our patient population was 0.51% (94/18,330). Moreover, using univariate analysis, hypouricemia was associated with age, gender, diet, drugs, and tea and coffee consumption. Multivariate analysis revealed that FEUA, drugs and tea consumption were associated with hypouricemia.Conclusion: Hypouricemia is a relatively uncommon finding among our patients and when it occurs it is frequently caused by inappropriate uricosuria.