Risk factors for human brucellosis in agro-pastoralist communities of south western Uganda: a case-control study.
Risk factors for human brucellosis in agro-pastoralist communities of south western Uganda: a case-control study.
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DOI：
10.1186/s13104-015-1361-z
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发表时间：
2015-09-04
影响因子：
1.8
通讯作者：
Rwego IB
中科院分区：
文献类型：
--
作者：
Asiimwe BB;Kansiime C;Rwego IB
布鲁氏菌病是一种在大多数发展中国家具有兽医、公共卫生和经济意义的人畜共患病。除了因失去工作时间而造成的收入损失外，这种疾病还可能导致永久性和致残的后遗症和可观的医疗费用。在乌干达基鲁胡拉区Nyabushozi进行了一项病例对照研究，以确定在这些社区将布鲁氏菌病传播给人类的危险因素。我们在前一项研究中进行了一项配对的病例对照研究，研究对象是标准的血清凝集试验阳性者，其效价为≥1：160。对照组是每个病例的两个邻居，性别和年龄匹配。采用结构化访谈问卷收集有关布鲁氏菌病潜在危险因素的数据。分类变量以比例表示，其关联性由卡方检验确定。采用双变量分析探讨疾病与布鲁氏菌病危险因素之间的关系。条件Logistic回归模型被用来使用优势比和95%的可信区间来估计疾病和危险因素之间的独立关联。共采访了45名患者和90名对照。45例患者中，男性21例(46.7%)，女性44例(48.9%)。感染的最显著危险因素是农牧民(P=0.05)、食用生牛酥油(P=0.03)和食用未经巴氏消毒的牛奶(P=0.02)。研究地区感染布鲁氏菌病的最大危险因素是农牧民、食用生牛酥油和食用生牛奶。我们建议在这些社区传播有关布鲁氏菌病风险和预防措施的健康教育包。本文的在线版本(doi：10.1186/s13104-0151361-z)包含补充材料，授权用户可以使用。
Brucellosis is a zoonosis of veterinary, public health and economic significance in most developing countries. The disease can result in permanent and disabling sequelae and considerable medical expenses in addition to loss of income due to loss of working hours. A case–control study was conducted in Nyabushozi, Kiruhura district, Uganda, so as to determine the risk factors for transmission of brucellosis to humans in these communities. We conducted a matched case–control study among participants in a previous study who were positive by the standard Serum Agglutination Test with titres ≥1:160. Controls were two neighbors for each case, matched by sex and age. A structured interviewer administered questionnaire was used to collect data on potential risk factors for brucellosis. Categorical variables were presented as proportions and their associations determined by Chi-square test. Bivariate analysis was performed to explore associations between the disease and the risk factors of brucellosis. Conditional logistic regression models were fitted to estimate independent associations between the disease and the risk factors using Odds Ratios and 95 % confidence intervals. A total of 45 cases and 90 controls were interviewed. Of the 45 cases, 21 (46.7 %) were male while 44/90 (48.9 %) of the controls were female. The most significant risk factors for infection being an agro-pastoralist (P = 0.05), consumption of raw cow ghee (P = 0.03) and consumption of unpasteurized milk (P = 0.02). The greatest risk factors for acquiring brucellosis in the study area were being an agro-pastoralist, consumption of raw cow ghee and consumption of unboiled milk. We recommend dissemination of health education packages regarding risks and prevention measures for brucellosis in these communities. The online version of this article (doi:10.1186/s13104-015-1361-z) contains supplementary material, which is available to authorized users.