Skill-memory consolidation in the striatum: critical for late but not early long-term memory and stabilized by cocaine.
Skill-memory consolidation in the striatum: critical for late but not early long-term memory and stabilized by cocaine.
复制标题
纹状体中的技能记忆巩固：对晚期长期记忆至关重要，但对早期长期记忆则不然，可卡因可以稳定该记忆。
DOI：
10.1016/j.bbr.2008.07.010
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发表时间：
2009
影响因子：
2.7
通讯作者：
Steiner,Heinz
中科院分区：
文献类型：
--
作者：
Willuhn,Ingo;Steiner,Heinz
感觉运动纹状体对包括技能学习在内的程序性学习很重要。我们之前的研究结果表明，这部分纹状体介导了在跑轮任务中运动技能的习得，并且这种技能学习依赖于纹状体D1多巴胺受体。在这里，我们研究了感觉运动纹状体是否也参与这种技能记忆的巩固，以及这种巩固是否被间接多巴胺受体激动剂可卡因修饰。大鼠在滚轮上训练2天（每天40分钟），学习一项新的运动技能，即控制滚轮运动的能力。在每次训练前，给小鼠注射毒品或可卡因（25mg/kg, i.p.）。训练结束后，立即给予2%利多卡因（1μl）的腔内输注或假输注。在训练前后反复测试车轮技能表现。我们的研究结果显示，试验后脑腔内输注利多卡因会破坏后期长期技能记忆（训练后6-26天），但不会影响早期长期记忆（训练后1天）。在训练期间练习较少的动物中，技能巩固更容易受到这种干扰。审判前服用可卡因可以防止审判后对技能巩固的破坏。这些发现表明，感觉运动纹状体对后期而非早期长期技能记忆的巩固至关重要。此外，可卡因似乎通过保护训练后的巩固过程来稳定运动记忆的形成。
The sensorimotor striatum is important for procedural learning, including skill learning. Our previous findings indicate that this part of the striatum mediates the acquisition of a motor skill in a running-wheel task and that this skill learning is dependent on striatal D1 dopamine receptors. Here, we investigated whether the sensorimotor striatum is also involved in the consolidation of this skill memory and whether this consolidation is modified by the indirect dopamine receptor agonist cocaine. Rats were trained on a running wheel for 2 days (40min/day) to learn a new motor skill, that is, the ability to control the movement of the wheel. Before each training session, the animals received an injection of vehicle or cocaine (25mg/kg, i.p.). Immediately following the training session, an intrastriatal infusion of 2% lidocaine (1μl) or a sham infusion were administered. Wheel-skill performance was tested before and repeatedly after the training. Our results show that post-trial intrastriatal infusion of lidocaine disrupted late-stage long-term skill memory (post-training days 6–26), but spared early long-term memory (1 day after the training). Skill consolidation was more susceptible to such disruption in animals that practiced less during the training. Cocaine given pre-trial prevented this post-trial disruption of skill consolidation. These findings indicate that the sensorimotor striatum is critical for the consolidation of late but not early long-term skill memory. Furthermore, cocaine appeared to stabilize motor-memory formation by protecting consolidation processes after the training.