Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers
Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers
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DOI：
10.1039/c5py00721f
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发表时间：
2015-01-01
影响因子：
4.6
通讯作者：
Cameron, N. R.
中科院分区：
文献类型：
--
作者：
Johnson, D. W.;Langford, C. R.;Cameron, N. R.
乳液模板法提供了一种制备具有明确形态的高度多孔聚合物的方法。本研究描述了这种多孔聚合物（聚HIPE）的制备通过光聚合的多官能硫醇和聚己内酯大分子单体。所得材料具有90%和95%的标称孔隙率，并且可以看出具有互连的孔形态，平均孔径约为60 μ m。使用成纤维细胞（L929）进行的初步生物相容性评估表明，聚合物能够支持细胞生长7天以上，降解产物浓度高达0.1 mg ml（-1）时对细胞无毒。
The emulsion templating process offers a route to highly porous polymers with well-defined morphologies. This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materials have nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 mu m. Initial biocompatibility assessments with fibroblast cells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml(-1).