Plasma lactoferrin reflects granulocyte activation in vivo.
Plasma lactoferrin reflects granulocyte activation in vivo.
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血浆乳铁蛋白反映体内粒细胞活化。
DOI：
10.1182/blood.v61.5.885.bloodjournal615885
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发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
L. Boxer
中科院分区：
文献类型：
--
作者：
J. Lash;T. Coates;J. Lafuze;R. Baehner;L. Boxer
N-甲酰基-甲亮苯丙氨酸（FMLP）在体外可引起多形核白细胞（PMN）分泌并变得“粘稠”。我们将这些事件与体内FMLP诱导的中性粒细胞减少症相关。将FMLP以0.01 μ g至1.0 μ g的剂量范围静脉内给予麻醉的兔。对照组接受磷酸盐缓冲盐水（PBS），FMLP的稀释剂。监测血压、呼吸频率和动脉血氧分压。高剂量和中等剂量的FMLP引起血压急剧但短暂的下降和呼吸频率的增加。FMLP输注前，血浆乳铁蛋白水平为6.4 +/- 4.1 μ g/ml，绝对粒细胞计数（AGC）为2008 +/- 1229（平均值+/- SD）。在注射FMLP之前，AGC与血浆乳铁蛋白水平之间存在正线性相关（R2 = 0.74，p小于0.01）。在FMLP注射后1分钟，AGC的百分比变化作为剂量的指数函数降低至低至基线的10%（R2 = 0.86，p = 0.002），并且乳铁蛋白的血浆浓度作为剂量的指数函数增加至高达30微克/ml（R2 = 0.84，p = 0.006）。因此，FMLP诱导的中性粒细胞减少症与血浆乳铁蛋白水平的增加相关，表明PMN在体内被诱导去铁。
N-formyl-met-leu-phe (FMLP) causes polymorphonuclear leukocytes (PMN) to secrete and become "sticky" in vitro. We related these events to in vivo FMLP-induced neutropenia. FMLP was intravenously administered to anesthetized rabbits in doses ranging from 0.01 microgram to 1.0 microgram. Controls received phosphate-buffered saline (PBS), the diluent for FMLP. Blood pressure, respiratory rate, and arterial Po2 were monitored. High and intermediate doses of FMLP caused a dramatic but transient decrease in blood pressure and an increase in respiratory rate. Prior to FMLP infusion, plasma lactoferrin level was 6.4 +/- 4.1 micrograms/ml, and the absolute granulocyte account (AGC) was 2008 +/- 1229 (mean +/- SD). There was a positive linear correlation between AGC and plasma lactoferrin level prior to injection of FMLP (R2 = 0.74, p less than 0.01). At 1 min after FMLP injection, the percent change in AGC decreased as an exponential function of dose to as low as 10% of baseline (R2 = 0.86, p = 0.002) and plasma concentration of lactoferrin increased as an exponential function of dose to as high as 30 micrograms/ml (R2 = 0.84, p = 0.006). Thus, FMLP-induced neutropenia is associated with increased levels of plasma lactoferrin, suggesting that PMN are induced to degranulate in vivo.
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全身输注乳铁蛋白引起的中性粒细胞减少症。
DOI：
--
发表时间：
1982
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Boxer,LA;Bjorksten,B;Bjork,J;Yang,HH;Allen,JM;Baehner,RL
通讯作者：
Baehner,RL
影响因子：
4.6
作者：
Jacob,HS
通讯作者：
Jacob,HS
影响因子：
15.9
作者：
BASS, DA;GONWA, TA;MCCALL, CE
通讯作者：
MCCALL, CE
体外循环期间发生的补体激活和中性粒细胞减少症。
DOI：
--
发表时间：
1981
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Hammerschmidt,DE;Stroncek,DF;Bowers,TK;Lammi-Keefe,CJ;Kurth,DM;Ozalins,A;Nicoloff,DM;Lillehei,RC;Craddock,PR;Jacob,HS
通讯作者：
Jacob,HS