ADH genotype does not modify the effects of alcohol on high-density lipoprotein.
ADH genotype does not modify the effects of alcohol on high-density lipoprotein.
复制标题
ADH 基因型不会改变酒精对高密度脂蛋白的影响。
DOI：
10.1097/01.alc.0000057940.57330.70
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Martin,NicholasG
中科院分区：
文献类型：
--
作者：
Whitfield,JohnB;O'Brien,MartinE;Nightingale,BrianN;Zhu,Gu;Heath,AndrewC;Martin,NicholasG
Background:Alcohol consumption has beneficial effects on mortality which are mainly due to reduction in cardiovascular disease. These are believed to be due, at least in part, to the increase in plasma high‐density lipoprotein (HDL) which is associated with alcohol consumption. It has been proposed thatADH3genotype modifies the relationships between alcohol intake and cardiovascular disease by altering the HDL response to alcohol. The aim of this paper was to test for effects ofADH2andADH3genotypes on the response of HDL components to habitual alcohol consumption.Methods:Adult male and female subjects were genotyped forADH2andADH3; and plasma HDL cholesterol, apolipoprotein A‐I, and apolipoprotein A‐II were measured. Nine hundred one subjects had bothADH2andADH3genotypes and HDL cholesterol results, while 753 had both genotypes and all three lipid results. The effect of alcohol intake on the three measured HDL components, and a factor score derived from them, was estimated for each of theADH2andADH3genotype groups.Results:All the measured components of HDL increased with increasing alcohol consumption over the range of intakes studied, 0–4 drinks per day. There were no significant interactions between alcohol consumption andADH2orADH3genotypes.Conclusions:The concept that alcohol dehydrogenase genotype and alcohol metabolic rate modify the effects of alcohol on plasma HDL concentration is not supported by our results.
