123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies
123I-metaiodobenzylguanidine myocardial scintigraphy with early images alone is useful for the differential diagnosis of dementia with Lewy bodies
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DOI：
10.1016/j.pscychresns.2016.12.011
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发表时间：
2017-03-30
影响因子：
2.3
通讯作者：
Kosaka, Kenji
中科院分区：
文献类型：
--
作者：
Manabe, Yuta;Inui, Yoshitaka;Kosaka, Kenji
123I-间碘苄基胍心脏闪烁扫描 (MIBG) 是一种有用的成像技术，可用于诊断路易体痴呆 (DLB)。然而，MIBG有一个严重的缺点，即它需要较长的检查时间。本研究的目的是统计评估 MIBG 早期心脏/纵隔比 (H/M) 对 DLB 鉴别诊断的有用性。总共有 113 名患者接受了检查，其中包括 32 名非 DLB 患者（19 名患有阿尔茨海默氏痴呆）和 79 名 DLB 患者。非 DLB 组的平均早期 H/M 比率为 2.83，DLB 组的平均早期 H/M 比率为 1.95。非 DLB 组的平均延迟 H/M 比率为 3.0，DLB 组的平均延迟 H/M 比率为 1.76。早期图像的截止点为 2.27，敏感性、特异性和诊断准确性分别为 65%、94% 和 73%，曲线下面积为 0.82，表明准确性中等。该分析表明，仅 MIBG 早期阶段的图像就足以鉴别诊断阿尔茨海默病和 DLB。
123I-metaiodobenzylguanidine cardiac scintigraphy (MIBG) is a useful imaging technique for the diagnosis of dementia with Lewy bodies (DLB). However, MIBG has a serious disadvantage in that it demands a long examination time. The objective of this study was to evaluate statistically the usefulness of the heart/ mediastinum ratio (H/M) from the early phase of MIBG for the differential diagnosis of DLB. In total, 113 patients were examined, including 32 non-DLB (19 with Alzheimer's dementia) and 79 DLB patients. The mean early-H/M ratio was 2.83 in the non-DLB group and 1.95 in the DLB group. The mean delayed-H/M ratio was 3.0 in the non-DLB group and 1.76 in the DLB group. With a cutoff point of 2.27 on early images, the sensitivity, specificity, and diagnostic accuracy were 65%, 94%, and 73%, respectively, and the area under the curve was 0.82, indicating moderate accuracy. This analysis indicates that images from the early phase of MIBG alone are sufficient for the differential diagnosis of Alzheimer's disease and DLB.