Interfering with leukocyte rolling -: a promising therapeutic approach in inflammatory skin disorders?
Interfering with leukocyte rolling -: a promising therapeutic approach in inflammatory skin disorders?
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DOI：
10.1016/s0165-6147(02)00039-1
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发表时间：
2003-02-01
影响因子：
13.8
通讯作者：
Schön, MP
中科院分区：
文献类型：
--
作者：
Boehncke, WH;Schön, MP
许多新的抗炎化合物是从研究工具中衍生出来的，这些工具旨在更好地了解炎症部位白细胞外渗的复杂过程。鉴于选择素介导的滚动是白细胞定位到皮肤的关键初始步骤，对这一机制的特异性干预是治疗皮肤炎的一个特别有吸引力的靶点。最近，针对与白细胞滚动有关的特定靶分子的选择性干扰而报道了一些令人兴奋的进展。
Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling.