Effects of Trp64Arg Mutation in the β3-Adrenergic Receptor Gene on Weight Loss, Body Fat Distribution, Glycemic Control, and Insulin Resistance in Obese Type 2 Diabetic Patients
Effects of Trp64Arg Mutation in the β3-Adrenergic Receptor Gene on Weight Loss, Body Fat Distribution, Glycemic Control, and Insulin Resistance in Obese Type 2 Diabetic Patients
复制标题
β3-肾上腺素能受体基因 Trp64Arg 突变对肥胖 2 型糖尿病患者体重减轻、体脂肪分布、血糖控制和胰岛素抵抗的影响
作者：
N. Sakane;Toshihide Yoshida;T. Umekawa;A. Kogure;Y. Takakura;M. Kondo
目的探讨β3肾上腺素能受体基因Trp 64 Arg突变对肥胖2型糖尿病患者体重减轻、体脂分布、血糖控制及胰岛素抵抗的影响。研究设计和方法我们测量了61名肥胖女性2型糖尿病患者在肥胖治疗12周前后的体重、腰臀比（WHR）、校正的静息代谢率、空腹血糖、空腹血清胰岛素水平、胰岛素抵抗指数（空腹血糖×空腹胰岛素/22.5）和HbA 1c水平。采用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）检测β3-肾上腺素能受体基因Mval多态性。结果在肥胖2型糖尿病患者中，携带该突变的患者（n = 24）WHR较高（P < 0.001），校正代谢率较低，血糖、血清胰岛素、胰岛素抵抗指数（P < 0.001）和HbA 1c水平较高（P = 0.016）。此外，与未发生突变的患者（n = 37）相比，发生突变的患者在减肥计划后体重、腰臀比、胰岛素抵抗指数和HbA 1c水平的下降幅度较小，尽管两组的食物摄入、运动和血清甲状腺激素水平相似。结论β3-肾上腺素能受体基因Trp 64 Arg等位基因可预测肥胖2型糖尿病患者减肥困难、腰臀比降低、血糖控制困难和胰岛素抵抗改善。
OBJECTIVE To investigate the effects of Trp64Arg mutation in the β3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients. RESEARCH DESIGN AND METHODS We measured body weight, waist-to-hip ratio (WHR), adjusted resting metabolic rate, fasting blood glucose, fasting serum insulin levels, insulin resistance index (fasting glucose × fasting insulin/22.5), and HbA1c levels before and after 12 weeks of obesity treatment in 61 obese women with type 2 diabetes. The Mval polymorphism of the β3-adrenergic receptor gene was determined by polymerase chain reaction-restriction fragment length polymorphism analysis. RESULTS Of obese type 2 diabetic patients, those with the mutation (n = 24) had a higher WHR (P < 0.001), a lower adjusted metabolic rate, and higher blood glucose levels, serum insulin levels, insulin resistance index (P < 0.001), and HbA1c levels (P = 0.016). Furthermore, patients with the mutation had smaller decreases in body weight, WHR, insulin resistance index, and HbA1c levels after the weight-loss program compared with patients without the mutation (n = 37), even though food intake, exercise, and serum thyroid hormone levels were similar in both groups. CONCLUSIONS These present findings show that the Trp64Arg allele of the β3-adrenergic receptor gene may predict difficulty in losing body weight, lowering WHR, and improving glycemic control and insulin resistance in obese patients with type 2 diabetes.
影响因子：
158.5
作者：
WALSTON, J;SILVER, K;SHULDINER, AR
通讯作者：
SHULDINER, AR
影响因子：
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作者：
R. Wing;R. Koeske;L. Epstein;M. Nowalk;W. Gooding;D. Becker
通讯作者：
R. Wing;R. Koeske;L. Epstein;M. Nowalk;W. Gooding;D. Becker