Genes that distinguish physiological and pathological angiogenesis
Genes that distinguish physiological and pathological angiogenesis
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DOI：
10.1016/j.ccr.2007.04.017
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发表时间：
2007-06-01
期刊：
影响因子：
50.3
通讯作者：
Croix, Brad St.
中科院分区：
文献类型：
--
作者：
Seaman, Steven;Stevens, Janine;Croix, Brad St.
为了解开正常血管系统的转录组，并确定它是如何被相邻的恶性细胞改变的，我们比较了来自8个正常静息组织，5个肿瘤和再生肝脏血管的内皮细胞的基因表达模式。器官特异性内皮细胞基因很容易确定，包括27个来自大脑。我们还确定了25个转录过表达的肿瘤与正常内皮细胞，包括13个没有发现在再生肝血管内皮细胞。大多数共有的血管生成基因在细胞周期控制中具有预期的作用，但那些特异于肿瘤内皮的基因主要是功能不确定的细胞表面分子。这些研究揭示了生理性和病理性血管生成之间的显著差异，这对于肿瘤特异性血管靶向治疗的发展可能是重要的。
To unravel the normal vasculature transcriptome and determine how it is altered by neighboring malignant cells, we compared gene expression patterns of endothelial cells derived from the blood vessels of eight normal resting tissues, five tumors, and regenerating liver. Organ-specific endothelial genes were readily identified, including 27 from brain. We also identified 25 transcripts overexpressed in tumor versus normal endothelium, including 13 that were not found in the angiogenic endothelium of regenerating liver. Most of the shared angiogenesis genes have expected roles in cell-cycle control, but those specific for tumor endothelium were primarily cell surface molecules of uncertain function. These studies reveal striking differences between physiological and pathological angiogenesis potentially important for the development of tumor-specific, vascular-targeted therapies.