Understanding the role of aneuploidy in tumorigenesis
Understanding the role of aneuploidy in tumorigenesis
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DOI：
10.1042/bst0370910
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发表时间：
2009-08-01
影响因子：
3.9
通讯作者：
Mc Gee, Margaret M.
中科院分区：
文献类型：
--
作者：
Bannon, John H.;Mc Gee, Margaret M.
非整倍体在肿瘤发生中的作用仍然知之甚少，尽管这两者之间的联系已有100多年的历史。最近的研究表明，非整倍体可以促进肿瘤细胞的生长和细胞死亡，细胞结局取决于诱导非整倍体的程度。有丝分裂检查点在维持基因组稳定性方面起着关键作用，一直是研究非整倍体不同结果的工作重点。在这篇文章中，我们回顾了涉及的分子机制，并讨论了有丝分裂检查点作为癌症治疗靶点的潜力。
The role of aneuploidy in tumorigenesis remains poorly understood, although the two have been known to be linked for more than 100 years. Recent studies indicate that aneuploidy can promote tumour cell growth and cell death and that the cellular outcome is dependent on the extent of aneuploidy induced. The mitotic checkpoint plays a pivotal role in the maintenance of genome stability and has been the focus of work investigating the distinct outcomes of aneuploidy. In the present article, we review the molecular mechanisms involved and discuss the potential of the mitotic checkpoint as a therapeutic target in cancer therapy.