Cytokeratin and filaggrin expression in nevus comedonicus
Cytokeratin and filaggrin expression in nevus comedonicus
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DOI：
10.1111/j.1600-0560.2006.00619.x
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发表时间：
2007-04-01
影响因子：
1.7
通讯作者：
Tsubura, Airo
中科院分区：
文献类型：
--
作者：
Kurokawa, Ichiro;Nakai, Yasuo;Tsubura, Airo
为了阐明粉刺痣角化异常的发病机制，我们使用抗角蛋白和抗细丝聚集蛋白（细丝聚集蛋白）抗体进行了免疫组织化学研究。粉刺痣与正常皮肤细胞角蛋白表达无显着差异。虽然丝聚蛋白仅在开放性粉刺的颗粒层中检测到，但在闭合性粉刺的浅层细胞和中间细胞中均检测到丝聚蛋白，这表明丝聚蛋白参与了闭合性粉刺的形成。丝聚蛋白相关的终末分化障碍可能在粉刺痣角质化异常的发病机制中发挥作用。
To elucidate the pathogenesis of abnormal keratinization in nevus comedonicus, we performed an immunohistochemical study using antikeratin and antifilaggrin (filament-aggregating protein) antibodies. There were no significant differences between nevus comedonicus and normal skin in cytokeratin expression. Although filaggrin was only detected in the granular layer in open comedones, filaggrin was detected in both superficial cells and also intermediate cells in closed comedones, suggesting that filaggrin is involved in the formation of closed comedones. The disorder of terminal differentiation related to filaggrin may play a role in the pathogenesis of abnormal keratinization in nevus comedonicus.