Metabolic Reprogramming Underlying Brain Metastasis of Breast Cancer.
Metabolic Reprogramming Underlying Brain Metastasis of Breast Cancer.
复制标题
乳腺癌脑转移的代谢重编程。
DOI：
10.3389/fmolb.2021.791927
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发表时间：
2021
影响因子：
5
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Liu B;Zhang X
脑转移是乳腺癌患者死亡的主要原因之一，具有进展快、预后差的特点，缺乏有效的治疗方法一直是临床上悬而未决的问题。大量研究表明，乳腺癌或脑转移瘤存在多种与细胞转移相关的代谢变化，因此，阐明转移级联反应中各个环节的代谢特征将为有效的治疗提供重要线索。本文就乳腺癌脑转移过程中细胞代谢模式的变化进行综述，探讨基于代谢重编程的潜在治疗靶点，为乳腺癌脑转移药物的设计和开发提供新的思路。
The development of brain metastasis is a major cause of death in patients with breast cancer, characterized by rapid progression of the disease and poor prognosis, and lack of effective treatment has existed as an unresolved issue clinically. Extensive research has shown that a variety of metabolic changes associated with cellular metastasis exist in primary breast cancer or brain metastases, therefore to elucidate metabolic characteristics at each step of the metastasis cascade will provide important clues to the efficient treatment. In this review, we discuss the changes in metabolic patterns of breast cancer cells at every step of metastasis for exploring the potential therapeutic target based on metabolic reprogramming, and provide new insights on the design and development of drugs for breast cancer brain metastasis.