Monte Carlo Simulation Study on Dose Enhancement by Gold Nanoparticles in Brachytherapy
Monte Carlo Simulation Study on Dose Enhancement by Gold Nanoparticles in Brachytherapy
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DOI：
10.3938/jkps.56.1754
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发表时间：
2010-06-01
影响因子：
0.6
通讯作者：
Yoon, Myonggeun
中科院分区：
文献类型：
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作者：
Cho, Sungkoo;Jeong, Jong Hwi;Yoon, Myonggeun
已经针对各种辐射源和不同浓度的金纳米颗粒研究了通过将高原子序数（Z）材料注射到肿瘤体积中的辐射剂量增强。近距离放射治疗采用小于0.5 MeV的低能光子，这确实是通过引入高Z材料来增强辐射剂量的最佳能量范围。本研究使用MCNPX（TM）代码来估计四种常见近距离放射治疗源（Cs-137，Ir-192，I-121和Pd-103）的金纳米颗粒的剂量增强。此外，顺铂（H6 Cl 2N 2 Pt），一种基于铂的化疗药物，用于评估剂量增强。参照计算的TG-43参数值对模拟源模型进行了评价。根据剂量增强因子（DEF）评价金纳米颗粒和顺铂在肿瘤区域的剂量增强。发现Cs-137、Ir-192、I-125和Pd-103源的平均DEF的最大值分别为1.03、1.11、3.43和2.17。低能量源的接近增强值显着高于高能量源的接近增强值。通过使用相同的方法计算顺铂引起的剂量增强，发现其与金纳米颗粒的剂量增强相当。对于水和Ir-192源中的5%浓度水平，顺铂的平均DEF的最大值为1.12。我们证实，顺铂可以应用于癌症治疗，化疗药物与放射治疗相结合。本文所呈现的结果将用于研究使用高原子序数材料的各种辐射方式在肿瘤区域中的剂量增强。
Radiation dose enhancement by injection of a high atomic number (Z) material into tumor volumes has been studied for various radiation sources and different concentrations of gold nanoparticles. Brachytherapy employs low energy photons of less than similar to 0.5 MeV, which indeed is the optimal energy range for radiation dose enhancement by introduction of high-Z material. The present study uses the MCNPX (TM) code to estimate the dose enhancement by gold nanoparticles for the four common brachytherapy sources (Cs-137, Ir-192, I-121, and Pd-103). Additionally, cisplatin (H6Cl2N2Pt), a platinum-based chemotherapeutic drug, was used to evaluate the dose enhancement. The simulated source models were evaluated with reference to the calculated TG-43 parameter values. The dose enhancement in the tumor region clue to the gold nanoparticles and cisplatin was evaluated according to the dose enhancement factor (DEF). The maximum values of the average DEFs were found to be 1.03, 1.11, 3.43, and 2.17 for the Cs-137, Ir-192, I-125, and Pd-103 sources, respectively. The close enhancement values for the low-energy sources were significantly higher than those for the high-energy sources. The dose enhancement due to cisplatin was calculated by using the same approach and was found to be comparable to that of the gold nanoparticles. The maximum value of the average DEF for cisplatin was 1.12 for the 5% concentration level in water and a Ir-192 source. We confirmed that cisplatin could be applied to cancer therapy that combines chemotherapeutic drugs with radiation therapy. The results presented herein will be used to study dose enhancement in tumor regions using various radiation modalities with high atomic number materials.